TABLE 1

Estimated Parameter Values for 4k_c Model

	Parameter
Study	V_B	K₁	k₂	k₃	V_ND	V_S	k_int
Blocked
A431^*	0.0736	0.0323	0.1190	0.0023	0.271	0.066	0.09910
A431^*	0.0408	0.0228	0.1370	0.0029	0.166	0.051	0.12700
A431^*	0.0539	0.0127	0.1250	0.0202	0.102	0.219	0.00047
U87	0.0236	0.0298	0.1290	0.0164	0.231	0.404	0.00215
U87	0.1140	0.0264	0.1690	0.0115	0.156	0.192	0.38100
Nonblocked
A431^*	0.0478	0.0291	0.0846	0.0139	0.344	0.510	0.00329
A431^*	0.0467	0.0159	0.1190	0.0302	0.134	0.430	0.00163
A431	0.0599	0.0291	0.1230	0.0425	0.237	1.072	0.00112
U373	0.0530	0.0341	0.1356	0.0228	0.251	0.612	–
U373	0.0701	0.0346	0.1660	0.0286	0.208	0.636	0.00095
U87	0.0546	0.0518	0.1340	0.0203	0.387	0.837	0.00313
U87	0.0860	0.0407	0.1520	0.0382	0.268	1.090	0.00094
U87	0.0174	0.0452	0.1330	0.0263	0.340	0.953	0.00245
U87	0.0956	0.0451	0.0929	0.0227	0.485	1.175	0.00092
U87^†	0.0238	0.0502	0.1640	0.0357	0.306	1.166	–
U87^†	0.1212	0.0331	0.1329	0.0626	0.249	1.661	–
U87^†	0.1396	0.0330	0.1078	0.0514	0.307	1.678	–

↵* Tumor located in thigh of mouse.
↵† 90-min dynamic PET scan.
Mean percent coefficient of variation for all 68 estimated parameters is 25% ± 20%. All tumors were located in mouse shoulder, and each dynamic PET scan was 60 min unless otherwise noted. Listed values correspond to open and closed black circles in Figure 5A; 4 studies without k_int values correspond to gray circles in Figure 5A. Units for K₁, k₂, k₃, and k_int are min⁻¹; V_ND, V_S, and V_B are unitless.