PiB DVR and clearance value | |||
---|---|---|---|
Demographic data | HCs (n = 27) | AD patients (n = 17) | DLB patients (n = 10) |
Age (y) | 72.6 ± 6.9 (range, 59–84) | 74.0 ± 11.3 (range, 56–91) | 72.0 ± 5.4 (range, 63–81) |
Female:male | 13:14 | 9:8 | 2:8 |
Education (y) | 12.5 ± 3.5 | 12.3 ± 4.8 | 9.3 ± 0.9 |
MMSE | 29.2 ± 0.9 | 22.1 ± 5.5* | 20.8 ± 7.2* |
Clinical dementia rating | 0.0 ± 0.0 | 1.2 ± 0.7* | 1.6 ± 0.8* |
ApoE ε4/non ε4 | 8/19 | 10/7 | 7/3 |
Neocortical† DVR | 1.22 ± 0.21 | 1.99 ± 0.23* | 1.67 ± 0.32*‡ |
White matter DVR | 1.39 ± 0.19§ | 1.36 ± 0.24§ | 1.33 ± 0.36 |
Neocortical clearance t1/2 (min) | 68.7 ± 11.6 | 112.5 ± 28.3* | 94.6 ± 25.7* |
White matter clearance t1/2 (min) | 224.4 ± 89.9§ | 268.7 ± 98.7§ | 229.1 ± 107.0§ |
↵* Statistically significant results, compared with controls (P < 0.05).
↵† Neocortex comprises average DVR values for frontal, parietal, cingulate, occipital, and lateral temporal cortices.
↵‡ Statistically significant results for DLB patients, compared with AD patients (P < 0.05).
↵§ Statistically significant results for white matter, compared with gray matter (P < 0.05).
ApoE = apolipoprotein E.