TABLE 2

Estimation of In Vivo Affinity of GSK189254 and Regional Concentration Histamine H₃ Sites

Subject no.	Kd (nM)		B_max (nM)
Subject no.	Kd (nM)	V_ND	Cerebellum	Cortex	Striatum
1	0.09	3.2 ± 1	0.50	1.4	2.1
2	0.10	2.7 ± 0.7	0.98	2.7	3.2

Kd = radioligand affinity.