TABLE 4

Biochemical and Hematologic Analyses of CT-26/tk-luc Tumor–Bearing BALB/c Mice at Fifth Week After Different Treatments

	Mean value after administration of 35 d
Parameter	¹¹¹In-vinorelbine liposome	¹¹¹In-liposome	¹¹¹In-DOTA	Vinorelbine liposome	NanoX liposome	Reference range
Blood cells
WBCs (10³/μL)	6.83 ± 0.27	6.12 ± 0.21	7.32 ± 0.34	8.99 ± 1.01	5.62 ± 0.12	3.2–12.7
RBCs (10⁶/μL)	7.78 ± 0.35	8.23 ± 0.32	7.86 ± 0.73	8.30 ± 0.91	10.23 ± 0.85	7.0–10.1
HGB (g/L)	12.30 ± 1.25	11.43 ± 1.31	12.96 ± 1.98	12.40 ± 1.54	12.53 ± 1.56	11.8–14.9
HCT	37.50 ± 1.54	37.34 ± 1.97	38.54 ± 2.23	37.27 ± 2.51	40.31 ± 3.58	36.7–46.8
PLTs (10³/μL)	1,312.21 ± 121.12	1,583.45 ± 211.45	1,487.56 ± 119.03	1,433.5 ± 107.88	1,116.23 ± 98.76	766–1,657
Serum
Liver function
ALP (U/L)	70.5 ± 4.21^*	72.27 ± 5.67^*	150.71 ± 7.96	89.12 ± 10.23^*	112.24 ± 12.56	62–209
Albumin (g/dL)	2.40 ± 0.02^*	2.40 ± 0.01^*	2.81 ± 0.06	2.4 ± 0.01^*	2.73 ± 0.01	2.5–4.8
ALT (U/L)	29.21 ± 1.23	29.89 ± 1.20	77.86 ± 7.33^†	37.69 ± 3.54	28.94 ± 2.54	28–132
AST (U/L)	219.00 ± 42.45	224.12 ± 45.89	131.86 ± 12.41	227.32 ± 24.21	145.67 ± 19.84	59–247
Kidney function
Creatinine (mg/dL)	0.25 ± 0.05	0.23 ± 0.07	0.29 ± 0.01	0.23 ± 0.06	0.24 ± 0.07	0.2–0.8
BUN (mg/dL)	17.05 ± 0.12^*	24.1 ± 0.32	35.29 ± 1.66^*	19.90 ± 1.21^*	27.57 ± 2.32	18–29

↵* P < 0.05.
↵† P < 0.01, are significantly different from NanoX liposome group by Student t test.
WBCs = white blood cells; RBCs = red blood cells; HGB = hemoglobin; HCT = hematocrit; PLTs = platelets; AST = aspartate aminotransferase.
Data are expressed as mean ± SE from 5 mice administered 37 MBq of ¹¹¹In-vinorelbine liposomes, ¹¹¹In-liposomes, ¹¹¹In-DOTA, or equivalent amount of unlabeled vinorelbine liposomes.