TABLE 2

Characteristics of Recurrences, Distant Metastases, and Second Primary Tumors That Developed in Study Population After Treatment

Patient no.	Original tumor site	TN stage	Initial therapy	Malignancy after treatment	Site of malignancy	¹⁸F-FDG PET detection^*	Confirmation diagnosis^†	Interval between¹⁸F-FDG PET and confirmation^‡	Treatment
1	OC	T4N2c	CR	Recurrence	Local	1	Histopathology	Direct	Salvage surgery
2	OC	T4N0	SR	Recurrence	Local	1	Histopathology	Direct	Palliative
3	OP	T4N2c	CR	Recurrence	Local	1	Histopathology	Direct	Palliative radiation
4	OP	T2N2b	R	Recurrence	Local	1	Histopathology	Direct	PDT
5	OC	T3N2b	SR	Recurrence	Local, pelvic bone	1	Histopathology, MRI	Direct	Palliative
6	OP	T3N0	SR	Recurrence	Local	1, 2, 4	Histopathology	9	Palliative
7	OC	T2N2b	SR	Recurrence	Local, neck	1, 2	Histopathology, USFNAC	3	Palliative
8	OC	T1N2b	SR	Recurrence	Neck	1, 2	USFNAC	3	Salvage surgery/radiation
9	OP	T4N2b	SR	Recurrence	Local, neck, lung	1	CT	Direct	Palliative
10	OP	T4N2c	CR	Recurrence	Local, neck, lung	1	CT	Direct	Palliative
11	OC	T4N2c	SR	Recurrence	Local, lung, kidney	1, 2, 3, 4	CT, USFNAC	9	Palliative
12	OP	T2N2c	R	Recurrence	Lung/esophagus	2, 3, 4	Histopathology, CT	18	Palliative
13	OC	T4N1	CR	Recurrence	Lung	1	CT	Direct	Palliative
14	OC	T4N0	SR	Second PMT	Esophagus	1, 2	Histopathology	3	Palliative
15	OC	T4N2c	SR	Second PMT	Lung T4N0	3	Histopathology	Direct	Lobectomy
16	OC	T4N0	SR	Second PMT	Lung T3N0	2, 3	Histopathology	3	Lobectomy
17	OC	T3N1	SR	Second PMT	Lung T1N0	4	Histopathology	Direct	Lobectomy
18	OC	T3N0	SR	Second PMT	Lung T1N0	1, 2	Histopathology	3	Lobectomy

↵* PET 1, 2, 3, and 4 refer to PET performed at 3, 6, 9, and 12 mo after therapy, respectively.
↵† Diagnosis of recurrence or second primary tumor was based on histopathology, or if histopathology was not available, on clinical follow-up and imaging.
↵‡ Time of diagnosis confirmation in months after first suggestion by PET return. For patient 6, PET 3 was cancelled because of rehabilitation after lobectomy, and for patient 11, PET 4 also detected carcinoma of kidney.
OC = oral cavity; CR = chemoradiation; SR = combination of surgery and radiotherapy; OP = oropharynx; R = radiotherapy; PDT = photodynamic therapy; USFNAC = ultrasound-guided fine-needle aspiration cytology; PMT = primary tumor.