Analysis of 177Lu-AMBA Tumor Uptake Calculated from Planar γ-Camera Acquisition
| Cell line | Average tumor weight (g) | ROI %ID | %ID/g |
|---|---|---|---|
| PC-3 (n = 5) | 0.28 ± 0.07 | 0.92 ± 0.31 | 2.70 ± 0.90 |
| LNCaP (n = 3) | 0.27 ± 0.09 | 0.15 ± 0.09 | 0.26 ± 0.13 |
| DU145 (n = 2) | 0.33 ± 0.03 | 0.16 ± 0.03 | 0.17 ± 0.04 |
Mice bearing PC-3, LNCaP, or DU145 tumors received intravenous injection of 177Lu-AMBA (27.75 MBq). After 24-h residence, mice were anesthetized and planar images were acquired. Tumor ROI were analyzed for 177Lu activity. Tumors were then excised, weighed, and counted. ROI = region of interest.