TABLE 4

Predictive Value of Therapy-Induced Parameter Changes for Early Response Evaluation, Assessed by Cox Regression Analysis

	OS			PFS
Parameter	HR	CI	P^*	HR	CI	P^*
Univariate
ΔMR_glc (all in FOV)^†	1.15	1.01–1.32	0.041	—	—	—
ΔMAD^†	1.40	1.06–1.85	0.023	1.34	1.04–1.74	0.026
Chemotherapy line^‡	—	—	—	—	—	—
Multivariate
ΔMR_glc (all in FOV)^†	1.22	1.05–1.41	0.008	—	—	—
Δk_ep^†	0.99	0.98–1.00	0.100	—	—	—
ΔMAD^†	—	—	—	1.48	1.10–1.99	0.010
Chemotherapy line^‡	—	—	—	3.15	1.17–8.49	0.023

↵* Significance assessed by Wald χ² test.
↵† Per 10% change.
↵‡ First line vs. higher lines.
CI = 95% confidence interval; all in FOV = estimated including all lesions in FOV of PET scanner.