TABLE 2

Biodistribution Data for ¹⁸F-FB-RMSH-1 and -2 in C57BL/6 Mice Bearing Subcutaneously Xenotransplanted B16F10 Murine Melanoma and Foxn1 Nude Mice Bearing A375M Human Melanoma

	¹⁸F-FB-RMSH-1
	B16F10					¹⁸F-FB-RMSH-2
Organ	1 h	2 h	4 h	B16F10 block (2 h)	A375M (2 h)	B16F10 (2 h)	A375M (2 h)
Tumor	1.97 ± 0.39	2.11 ± 0.12	0.83 ± 0.05	1.62 ± 0.11	0.33 ± 0.04	1.36 ± 0.18	0.42 ± 0.19
Blood	1.98 ± 0.57	0.76 ± 0.19	0.39 ± 0.18	1.21 ± 0.05	0.43 ± 0.02	0.40 ± 0.07	0.25 ± 0.05
Heart	1.30 ± 0.44	0.62 ± 0.15	0.33 ± 0.12	0.76 ± 0.03	0.56 ± 0.17	0.30 ± 0.03	0.22 ± 0.03
Liver	5.62 ± 2.14	2.45 ± 0.45	1.15 ± 0.37	4.36 ± 0.63	1.35 ± 0.07	3.70 ± 0.63	2.92 ± 0.45
Lung	6.42 ± 2.50	2.39 ± 0.62	1.32 ± 0.40	4.00 ± 0.71	1.75 ± 0.17	1.22 ± 0.12	1.16 ± 0.20
Muscle	0.61 ± 0.11	0.27 ± 0.07	0.17 ± 0.04	0.40 ± 0.08	0.21 ± 0.01	0.21 ± 0.02	0.19 ± 0.09
Spleen	1.32 ± 0.48	0.81 ± 0.29	0.28 ± 0.04	0.53 ± 0.13	0.54 ± 0.07	0.74 ± 0.18	0.46 ± 0.07
Brain	0.14 ± 0.06	0.08 ± 0.01	0.04 ± 0.01	0.06 ± 0.00	0.04 ± 0.00	0.04 ± 0.01	0.03 ± 0.00
Intestine	1.28 ± 0.44	0.95 ± 0.35	0.68 ± 0.37	2.70 ± 0.46	0.44 ± 0.07	0.47 ± 0.09	0.78 ± 0.72
Stomach	2.33 ± 0.60	0.82 ± 0.29	0.52 ± 0.19	1.86 ± 0.23	0.41 ± 0.05	0.41 ± 0.07	0.31 ± 0.13
Pancreas	0.66 ± 0.18	0.24 ± 0.08	0.28 ± 0.18	0.41 ± 0.06	0.19 ± 0.04	0.11 ± 0.03	0.10 ± 0.01
Bone	1.32 ± 0.35	0.83 ± 0.10	0.30 ± 0.07	1.40 ± 0.91	0.46 ± 0.04	0.36 ± 0.20	0.30 ± 0.15
Kidney	7.72 ± 1.19	5.42 ± 0.50	5.09 ± 1.07	9.81 ± 0.25	5.02 ± 0.10	17.8 ± 1.80	16.86 ± 2.93
Uptake ratio
Tumor to blood	1.01 ± 0.08	2.59 ± 0.26	1.65 ± 0.11	1.48 ± 0.10	0.77 ± 0.14	3.49 ± 0.92	1.98 ± 1.16
Tumor to muscle	3.24 ± 0.06	7.43 ± 0.81	5.24 ± 1.43	3.13 ± 0.74	1.57 ± 0.26	7.01 ± 2.95	2.53 ± 1.19

Data are mean ± SD %ID/g after intravenous injection of 1.28–1.64 MBq (34.7–44.4 μCi) of tracer (n = 3).