IC50 Values of α-MSH Analogs and Their Expected and Measured MW for [M+H]+ by ESI-MS or MALDI-TOF-MS
| Peptides | Expected | Measured | IC50 (nM) |
|---|---|---|---|
| Ac-d,Lys-CCMSH (Arg11) | 1,605.9 | 1,605.6 | ND |
| RMSH-1 | 1,804.1 | 1,803.7 | 5.4 ± 0.7 |
| RMSH-2 | 1,804.1 | 1,804.7 | 13.9 ± 1.4 |
| 19F-FB-RMSH-1 | 1,926.2 | 1,927.8 | 5.7 ± 0.7 |
| 19F-FB-RMSH-2 | 1,926.2 | 1,928.2 | 9.0 ± 1.0 |
ND = not determined.