Rate Constants, VT, and Goodness of Fit After P-gp Blockade, Using 1-Tissue-Compartment Model
| Rate constant | Goodness of fit | ||||
|---|---|---|---|---|---|
| Region | K1 (mL·cm−3·min−1) | k2 (min−1) | VT (mL·cm−3) | AIC | MSC |
| Frontal cortex | 0.201 ± 0.031 (1.1 ± 0.2) | 0.011 ± 0.004 (2.7 ± 0.7) | 21.1 ± 8.3 (1.9 ± 0.6) | 94 ± 9 | 4.1 ± 0.2 |
| Anterior cingulate | 0.251 ± 0.048 (1.7 ± 0.5) | 0.011 ± 0.004 (3.9 ± 1.5) | 24.2 ± 9.6 (2.8 ± 1.1) | 121 ± 19 | 3.3 ± 0.5 |
| Temporal cortex | 0.25 ± 0.032 (1.1 ± 0.3) | 0.011 ± 0.003 (2.6 ± 0.9) | 24.2 ± 8.7 (1.9 ± 0.7) | 96 ± 16 | 4 ± 0.4 |
| Parietal cortex | 0.229 ± 0.036 (1.1 ± 0.2) | 0.011 ± 0.004 (2.4 ± 0.6) | 22.6 ± 9.1 (1.7 ± 0.4) | 93 ± 8 | 4.1 ± 0.1 |
| Hippocampus | 0.236 ± 0.057 (1.9 ± 0.2) | 0.011 ± 0.003 (4.4 ± 1.0) | 22.7 ± 9.3 (3.1 ± 0.9) | 132 ± 7 | 2.8 ± 0.4 |
| Occipital cortex | 0.233 ± 0.035 (1.0 ± 0.2) | 0.012 ± 0.005 (2.2 ± 0.7) | 22.3 ± 9.4 (1.6 ± 0.6) | 86 ± 13 | 4.4 ± 0.4 |
| Putamen | 0.331 ± 0.040 (1.0 ± 0.2) | 0.011 ± 0.004 (2.2 ± 0.6) | 31.7 ± 12.4 (1.6 ± 0.5) | 87 ± 10 | 4.4 ± 0.2 |
| Cerebellum | 0.314 ± 0.051 (1.2 ± 0.4) | 0.014 ± 0.004 (2.4 ± 0.9) | 24.2 ± 9.3 (1.8 ± 0.7) | 102 ± 23 | 3.9 ± 0.8 |
AIC = Akaike information criterion; MSC = model selection criterion.
P-gp was blocked by DCPQ (8 mg/kg, intravenously) administered 30 min before injection of 11C-dLop. For each brain region, identifiability is listed in parentheses and is expressed as percentage of variable itself. Values are mean ± SD from 4 monkeys.