TABLE 3

Serial Changes in Bone Turnover Markers and BMD During Treatment with Alendronate

MarkerBaselineTreatment with alendronate
3 mo6 mo12 mo
BSALP (U/L)27.0 (11.3)22.6 (8.7)19.7 (9.0)*18.5 (6.6)*
NTx (nmol BCE/nmol Cr)56.5 (22.4)26.2 (8.4)†22.3 (8.0)†20.5 (6.2)†
Lumbar spine SUV5.2 (0.72)4.8 (0.48)*4.4 (0.48)†
Femoral neck SUV2.5 (0.47)2.2 (0.53)1.8 (0.51)†
Lumbar spine BMD (g/cm2)0.78 (0.079)0.80 (0.076)0.84 (0.077)*
Lumbar spine T-score−2.2 (0.90)−2.0 (0.73)−1.6 (0.75)*
Femoral neck BMD (g/cm2)0.72 (0.093)0.72 (0.090)0.77 (0.084)
Femoral neck T-score−2.9 (0.88)−2.7 (0.85)−2.3 (0.74)

  • ↵* P < 0.05.

  • ↵† P < 0.01 vs. baseline.

  • BCE = bone collagen equivalent; Cr = creatinine.

  • Data are mean followed by SD in parentheses.