Radiochemical Yields of Product 18F-12 and By-Product A with Different Anion Activation Phase Transfer Catalysts
| Mean ± SD (%) | ||
|---|---|---|
| Phase transfer catalyst | 18F-12 | By-product A |
| Cs2CO3 | 9.5 ± 2.1 | |
| (Kryptofix 2.2.2)2CO3 | 49.9 ± 3.7 | 30.75 ± 6.2 |
| (Kryptofix 2.2.2)2C2O4/CO3 | 6.3 ± 3.2 | |
| Tetrabutylammonium hydroxide | 2.3 ± 0.4 | 41.1 ± 5.5 |
| TBAHCO3 | 47.6 ± 10.3 | 12.6 ± 5.6 |
[12] = 14.25 mmol/L, DMF, 130°C, 10 min (n = 3), analysis by TLC.