TABLE 1

Comparative Biodistribution Studies of 18F-FPA and 14C-Acetate in Mice

%ID/g*Tumor-to-organ ratio
Organ18F-FPA14C-acetate18F-FPA14C-acetate
Blood6.88 ± 0.640.02 ± 0.021.0316.91
Tumor†7.08 ± 0.800.36 ± 0.081.001.00
Heart5.46 ± 0.630.25 ± 0.031.301.44
Lungs4.00 ± 0.260.85 ± 0.111.770.42
Liver5.61 ± 0.500.67 ± 0.171.260.53
Spleen4.36 ± 0.850.68 ± 0.161.620.52
Stomach2.53 ± 1.040.77 ± 0.422.800.47
Small intestine4.37 ± 1.150.81 ± 0.131.620.44
Large intestine3.71 ± 1.090.56 ± 0.201.910.64
Kidneys4.17 ± 0.600.58 ± 0.141.700.62
Muscle3.66 ± 0.500.17 ± 0.031.942.06
Bone1.68 ± 0.540.29 ± 0.114.231.22
Brain5.57 ± 0.330.30 ± 0.021.271.17

  • ↵* Mice euthanized 1 h after simultaneous administration of 18F-FPA and 14C-acetate via tail vein injection. Values are mean ± SD of mean (n = 4).

  • ↵† CWR22rv1 tumors.