Median Survival of Mice Intravesically Instilled with EJ28-Luc Tumor Cells After Intravesical Therapy with 213Bi-Anti-EGFR, Mitomycin C, or Unlabeled Anti-EGFR-mAb at Different Time Points After Cell Instillation
| Median survival after intravesical instillation of... | ||||
|---|---|---|---|---|
| Therapy (time after cell inoculation) | 213Bi-anti-EGFR-mAb | Mitomycin C | Unlabeled anti-EGFR-mAb | |
| 0.37 MBq | 0.925 MBq | 40 μg | 2 μg | |
| 1 h | >300 d (1 mouse died on day 297) | >300 d (1 mouse died on day 286) | 289 d (IQR, 110 to >300 | 89 d (IQR, 53 to 125) |
| 7 d | 49 d (IQR, 34 to >300) | >300 d (2 mice died on days 173 and 257) | 251 d (IQR, 138 to >300) | n.d. |
| 14 d | n.d. | 55 d (IQR, 23 to > 300) | n.d. | n.d. |
Median survival of controls (n =10) was 41 d (IQR, 25–59). IQR = interquartile range; n.d. = not determined.