TABLE 1

Anticipated Imaging Responses of TdR and Its Analogs to Various Chemotherapeutic Agents

Drug	Target	Effect on tumor size	Anticipated effect on TK1	Anticipated imaging response
Cisplatin	DNA formation	↓	↓	↓
Cyclophosphamide	DNA formation	↓	↓	↓
Doxorubicin	DNA formation	↓	↓	↓
Gemcitabine	DNA formation	↓	↓	↓
Actinomycin D	DNA polymerase	↓	↓	↓
Irinotecan	Topoisomerase	↓	↓	↓
Vincristine	Microtubules	↓	↓	↓
NVP-LAQ824	TK synthesis	NC	↓	↓
PKI-166	Epidermal growth factor receptor tyrosine kinase	NC	↓	↓
Bevacizumab	Vascular endothelial growth factor	NC	↓	↓
Rituximab	B lymphocytes	↓	NC	↓
5-Fluorouracil, capecitabine	TS blockers	↓	↑	↑, then ↓
Methotrexate	Folic acid synthesis	↓	↑	↑, then ↓