Alkyl Substituents Affecting Partition Coefficients of 2-Nitroimidazole Imaging Agents
| Name | -R structure | Partition coefficient* |
|---|---|---|
| SR2508 | -CH2CONHCH2CH2OH | 0.046 |
| FETA | -CH2CONHCH2CH2F | 0.16 |
| FETNIM | -CH2CHOHCHOHCH2F | 0.17 |
| MISO | -CH2CHOHCH2OCH3 | 0.43 |
| FMISO | -CH2CHOHCH2F | 0.44 (0.41) |
| EF1 | -CH2CONHCH2CH2CH2F | 0.20 |
| EF3 | -CH2CONHCH2CH2CF3 | 1.25 |
| TF-MISO | -CH2CHOHCH2OCH2CF3 | 2.6 |
| EF5 | -CH2CONHCH2CF2CF3 | 5.7 |
↵* Octanol/water value.