Tissue Distribution Ratios After Coinjection in Mice of 211At-Trastuzumab and 125I-Trastuzumab Labeled by Conventional Procedure
| Tissue distribution ratio* at: | |||||
|---|---|---|---|---|---|
| Tissue | 1 h | 3 h | 6 h | 11 h | 24 h |
| Blood | 0.92 ± 0.02 | 0.91 ± 0.01 | 0.98 ± 0.04 | 1.01 ± 0.02 | 0.96 ± 0.02 |
| Neck | 1.03 ± 0.03 | 1.11 ± 0.08 | 1.40 ± 0.12 | 1.13 ± 0.07 | 1.48 ± 0.15 |
| Salivary gland | 1.14 ± 0.10 | 1.15 ± 0.11 | 1.28 ± 0.04 | 1.16 ± 0.07 | 1.18 ± 0.05 |
| Heart | 0.99 ± 0.01 | 0.98 ± 0.09 | 1.03 ± 0.04 | 1.02 ± 0.03 | 0.98 ± 0.03 |
| Lung | 1.03 ± 0.01 | 1.04 ± 0.03 | 1.11 ± 0.04 | 1.12 ± 0.05 | 1.06 ± 0.05 |
| Liver | 0.87 ± 0.03 | 0.87 ± 0.09 | 0.81 ± 0.03 | 0.84 ± 0.05 | 0.85 ± 0.06 |
| Stomach | 1.34 ± 0.06 | 2.03 ± 0.25 | 1.85 ± 0.18 | 2.12 ± 0.33 | 1.62 ± 0.15 |
| Small intestine | 0.99 ± 0.01 | 0.97 ± 0.03 | 0.97 ± 0.05 | 0.94 ± 0.09 | 0.94 ± 0.03 |
| Large intestine | 1.03 ± 0.05 | 1.06 ± 0.05 | 1.06 ± 0.06 | 0.93 ± 0.07 | 0.92 ± 0.08 |
| Kidney | 0.93 ± 0.01 | 0.96 ± 0.02 | 1.02 ± 0.02 | 1.03 ± 0.03 | 1.01 ± 0.01 |
| Muscle | 1.04 ± 0.05 | 1.08 ± 0.09 | 1.11 ± 0.04 | 0.96 ± 0.06 | 0.97 ± 0.04 |
| Spleen | 0.98 ± 0.05 | 0.98 ± 0.07 | 0.80 ± 0.04 | 0.82 ± 0.11 | 0.92 ± 0.08 |
↵* Results are given as mean ± SD (%IA/g for 211At/%IA/g for 125I) for 4 animals at each time point.