Univariate Analysis: Relationship Between Patient Characteristics and Effective Half-Life After Either Thyroid Hormone Withdrawal or rhTSH Injections
| rhTSH patients (n = 36, effective half-life, 10.5 ± 1.5) | Withdrawal patients without metastasis and with T1–T3 tumor (n = 167, effective half-life, 15.2 ± 4.7) | Withdrawal patients with metastasis or T4 tumor (n = 51, effective half-life, 17.2 ± 7.1) | Withdrawal patients (n = 218, effective half-life, 15.7 ± 5.3) | |||||
|---|---|---|---|---|---|---|---|---|
| Characteristic | % Mean ± SD | P | % Mean ± SD | P | % Mean ± SD | P | % Mean ± SD | P |
| Age (y) | 44.1 ± 14.1 | 0.6 | 47.2 ± 14.9 | 0.9 | 49.5 ± 17.8 | 0.1 | 47.9 ± 15.7 | 0.2 |
| Sex | 0.4 | 0.2 | 0.3 | 0.02 | ||||
| Male | (19.5%) 11.0 ± 1.8 | (29.3%) 16.3 ± 6.9 | (41.9%) 18.6 ± 5.7 | (31.8%) 17.1 ± 6.6 | ||||
| Female | (80.5%) 10.4 ± 1.4 | (70.7%) 14.8 ± 3.4 | (58.1%) 16.2 ± 8.0 | (68.2%) 15.0 ± 4.5 | ||||
| Creatinine (μmol/L) | 73.1 ± 13.7 | 0.1 | 93.5 ± 18.7 | 0.0002 | 114.6 ± 166.1 | 0.02 | 98.1 ± 26.1 | 0.0001 |
| Thyroglobulin (ng/mL) | 81.4 ± 444.8 | 0.5 | 24.8 ± 143.1 | 0.5 | 7,100 ± 14,550 | 0.2 | 1,435 ± 7,012 | 0.02 |
| TSH (mIU/L) | 87.5 ± 26.3 | 0.7 | 69.6 ± 25.5 | 0.2 | 69.0 ± 28.6 | 0.5 | 68.9 ± 26.1 | 0.8 |
| Previous 131I treatments (n) | 0.3 ± 1.1 | 0.05 | 0.4 ± 0.9 | 0.9 | 2.3 ± 1.7 | 0.2 | 0.8 ± 1.3 | 0.9 |
| Histology | 0.3 | 0.2 | 0.07 | 0.02 | ||||
| Papillary | (78.8%) 10.3 ± 1.3 | (89.7%) 14.9 ± 3.4 | (60.5%) 15.5 ± 5.3 | (82.7%) 15.1 ± 3.8 | ||||
| Follicular | (21.2%) 11.0 ± 2.1 | (10.3%) 18.2 ± 10.5 | (39.5%) 19.9 ± 8.8 | (17.3%) 19.0 ± 9.6 | ||||
| Tumor | 0.6 | 0.7 | 0.5 | 0.4 | ||||
| T1 and T2 | (82.8%) 10.5 ± 1.3 | (65.8%) 15.4 ± 5.4 | (32.5%) 15.9 ± 6.2 | (53.2%) 15.4 ± 5.4 | ||||
| T3 and T4 | (17.2%) 10.8 ± 2.2 | (34.2%) 15.1 ± 3.4 | (67.5%) 17.7 ± 7.8 | (46.8%) 16.1 ± 5.4 | ||||
| Node | 0.9 | 0.8 | 0.3 | 0.3 | ||||
| N0 and Nx | (50.0%) 10.5 ± 1.3 | (42.2%) 15.3 ± 6.3 | (34.9%) 19.2 ± 9.4 | (40.9%) 16.2 ± 7.0 | ||||
| N1 | (50.0%) 10.5 ± 1.7 | (57.8%) 15.1 ± 3.2 | (65.1%) 16.2 ± 5.5 | (59.1%) 15.3 ± 3.8 | ||||
| Metastasis | 0.03 | |||||||
| M0 | (75.9%) 15.2 ± 4.8 | |||||||
| M1 | (24.1%) 18.0 ± 7.3 | |||||||