Global Values of CBF and K* for AA in Healthy Controls and Patients with AD, Before and After Correction for PVE
| PVE-uncorrected | PVE-corrected | ||||
|---|---|---|---|---|---|
| Group | Parameter | CBF (mL/100 g/min) | K* (μL/min/cm3) | CBF (mL/100 g/min) | K* (μL/min/cm3) |
| Control | Number† | 7 | 9 | 7 | 9 |
| Mean ± SD | 38.0 ± 5.3 | 4.7 ± 0.6 | 61.6 ± 10.1 | 6.9 ± 0.8 | |
| CV (%) | 13.8 | 12.0 | 16.4 | 11.9 | |
| AD | Number† | 6 | 8 | 6 | 8 |
| Mean ± SD | 27.1 ± 7.6‡ | 5.5 ± 0.8‡ | 48.3 ± 14.0 | 8.7 ± 1.4§ | |
| CV (%) | 28.1 | 15.2 | 28.9 | 15.7 | |
| Difference (%) | −28.6 | 18.3 | −21.5 | 26.4 | |
↵* Differs significantly from control mean by 2-tailed t test.
↵† Number of CBF scans is fewer than K* scans because of failure of some CBF scans.
↵‡ P ≤ 0.05.
↵§ P ≤ 0.01.
Values were calculated from mean values from 90 hemispheric regions identified in stereotactic atlas of Tzourio-Mazoyer et al. (35) and were compared by 2-tailed t tests.