Sex-Related Effects of Cyclosporine A on Biodistribution Profile of 99mTc(N)-DBODC(5)
| % dose/g for 3 rats (mean ± SD) | ||||||||
|---|---|---|---|---|---|---|---|---|
| Female (baseline) | Female (cyclosporin A) | Male (baseline) | Male (cyclosporin A) | |||||
| Organ | 30 min | 120 min | 30 min | 120 min | 30 min | 120 min | 30 min | 120 min |
| Blood | 0.02 ± 0.00 | 0.01 ± 0.00 | 0.03 ± 0.01 | 0.01 ± 0.00 | 0.12 ± 0.02 | 0.15 ± 0.01 | 0.12 ± 0.03 | 0.05 ± 0.01 |
| Heart | 3.02 ± 0.30 | 2.75 ± 0.04 | 3.51 ± 0.19 | 3.50 ± 0.20 | 3.00 ± 0.21 | 2.72 ± 0.19 | 3.71 ± 0.51 | 3.51 ± 0.09 |
| Lungs | 0.57 ± 0.13 | 0.29 ± 0.02 | 0.91 ± 0.05 | 0.54 ± 0.03 | 0.74 ± 0.02 | 0.62 ± 0.06 | 1.64 ± 0.41 | 0.76 ± 0.16 |
| Liver | 0.64 ± 0.02 | 0.11 ± 0.01 | 0.72 ± 0.06 | 0.69 ± 0.11 | 0.88 ± 0.08 | 0.63 ± 0.09 | 2.83 ± 0.10 | 1.80 ± 0.60 |
| Kidneys | 6.70 ± 0.98 | 3.32 ± 0.21 | 8.21 ± 0.98 | 9.57 ± 0.89 | 7.83 ± 0.13 | 5.69 ± 1.25 | 13.82 ± 1.00 | 12.96 ± 2.46 |
| Small intestine | 6.22 ± 0.50 | 6.91 ± 2.39 | 9.78 ± 0.58 | 15.08 ± 2.09 | 8.96 ± 1.75 | 12.14 ± 4.17 | 10.65 ± 1.32 | 8.02 ± 1.63 |
| Intestinal tissue* | 7.80 ± 0.39 | 8.92 ± 2.00 | 59.86 ± 10.39 | 44.65 ± 1.48 | 66.33 ± 0.65 | 61.51 ± 9.21 | 63.64 ± 10.90 | 28.18 ± 4.57 |
| Endoluminal* | 92.00 ± 0.39 | 90.05 ± 2.00 | 40.14 ± 10.39 | 55.35 ± 1.48 | 33.67 ± 0.65 | 38.49 ± 9.21 | 36.36 ± 10.90 | 71.82 ± 4.57 |
| Urine | 0.57 ± 0.09 | 16.61 ± 1.40 | 8.94 ± 0.29 | 8.27 ± 3.40 | 12.78 ± 4.22 | 14.82 ± 1.44 | NA | 16.91 ± 2.59 |
| Heart-to-lung ratio | 5.29 | 9.48 | 3.85 | 6.48 | 4.04 | 4.38 | 2.26 | 4.62 |
| Heart-to-liver ratio | 4.71 | 25.00 | 4.87 | 5.07 | 3.39 | 4.30 | 1.31 | 1.95 |
↵* As relative percentage of total small-intestinal activity.
NA = data not available.