Non–Metabolite-Corrected Myocardial Retention Index and Washout Rate of Radiotracers With and Without Treatment With DMI
| Retention index (%/min at 40 min) | Washout rate (%/min between 10 and 60 min) | |||||
|---|---|---|---|---|---|---|
| Radiotracer | Without intervention (n = 4) | DMI chase (n = 4) | DMI pretreatment (n = 1) | Without intervention (n = 4) | DMI chase (n = 4) | DMI pretreatment (n = 1) |
| HED | 7.38 ± 0.82 | 3.28 ± 0.60* | 0.21 ± 0.35† | 0.13 ± 0.23 | 1.86 ± 0.57* | ‡ |
| PHEN | 3.43 ± 0.45 | 2.95 ± 0.51* | 0.24 ± 0.25† | 1.13 ± 0.35 | 1.51 ± 0.16 | ‡ |
| EPI | 4.24 ± 0.59 | 4.02 ± 0.99 | 0.22 ± 0.30† | 0.50 ± 0.24 | 0.61 ± 0.28 | ‡ |
| EPI (low specific radioactivity) | 3.87 ± 0.81 | — | — | 0.69 ± 0.17 | — | — |
↵* P < 0.05 vs. animals without intervention.
↵† Single-case observation precludes statistical testing, but values are markedly reduced.
↵‡ Complete washout of radiotracer from myocardium in first 10 min in DMI pretreated rats.
Values are average ± SD from septal, lateral, inferior, anterior, and apex regions of left ventricle.