Time-Dependent Uptake of 99mTc(I)-Estradiol-Pyridin-2-yl Hydrazine Derivative
| %ID/g at the following time (h) after injection: | |||
|---|---|---|---|
| Organ | 1 | 3 | 24 |
| Kidneys | 1.70 ± 0.33 | 1.31 ± 0.06 | 1.19 ± 0.12 |
| Adrenal glands | 1.87 ± 0.75 | 3.10 ± 0.46 | 0.58 ± 0.15 |
| Heart | 1.17 ± 0.23 | 1.61 ± 0.51 | 0.86 ± 0.12 |
| Small intestine | 0.44 ± 0.20 | 1.87 ± 0.54 | 0.68 ± 0.05 |
| Large intestine | 0.28 ± 0.06 | 3.24 ± 0.95 | 0.89 ± 0.19 |
| Liver | 9.48 ± 0.99 | 8.34 ± 0.18 | 7.84 ± 0.24 |
| Urinary bladder | 0.19 ± 0.05 | 0.96 ± 0.27 | 5.99 ± 4.34 |
| Blood | 2.47 ± 0.07 | 2.79 ± 0.21 | 1.02 ± 0.39 |
| Bone | 0.28 ± 0.16 | 0.14 ± 0.01 | 0.85 ± 0.53 |
| Lungs | 1.49 ± 0.39 | 1.12 ± 0.19 | 0.83 ± 0.17 |
| Stomach | 0.85 ± 0.14 | 1.08 ± 0.37 | 0.34 ± 0.04 |
| Muscle | 0.10 ± 0.01 | 0.18 ± 0.03 | 0.35 ± 0.10 |
| Mammary glands | 1.21 ± 0.26 | 3.07 ± 0.40 | 1.59 ± 0.59 |
| Uterus | 1.32 ± 0.37 | 1.48 ± 0.10 | 1.60 ± 0.17 |
| Ovaries | 1.40 ± 0.32 | 1.19 ± 0.26 | 0.97 ± 0.25 |
| Brain | 0.06 ± 0.01 | 0.10 ± 0.01 | 0.02 ± 0.01 |
Uptake was determined from biodistribution studies of 99mTc(I)-estradiol-pyridin-2-yl hydrazine derivative in selected organs of 8- to 10-wk-old female C57BL/6 mice in diestrus. Data represent mean ± SEM from at least 6 determinations.