Stability of 99mTc(I)-Estradiol-Pyridin-2-yl Hydrazine Derivative
| % Stability in presence of: | |||||
|---|---|---|---|---|---|
| Time (h) | 1 mM histidine | 1 mM cysteine | 1 mM DTPA | PBS | C57BL/6 serum |
| 1 | 88.8 ± 0.7 a | 89.2 ± 0.4 | 97.6 ± 0.2 | 97.4 ± 0.5 | 97.4 ± 0.6 |
| 3 | 86.9 ± 0.4 | 84.7 ± 2.2 | 95.2 ± 0.9 | 96.1 ± 1.2 | 95.5 ± 1.1 |
| 24 | 76.3 ± 2.8 | 68.2 ± 2.7 | 92.0 ± 4.0 | 97.3 ± 1.4 | 93.9 ± 2.3 |
Samples were incubated at 37°C in 1 mM histidine, 1 mM cysteine, 1 mM DTPA, PBS, and C57BL/6 serum. Stability was assessed by HPLC and instant thin-layer chromatography. Data represent mean ± SEM from 3 determinations.