TABLE 2

Rat Tissue Distribution of ^99mTc-(CO)₃D(C₈)Lisinopril

	%ID/g
Tissue	10 min	30 min	1 h	2 h
Blood	0.15 ± 0.04	0.08 ± 0.02	0.04 ± 0.02	0.04 ± 0.01
(+lisinopril)	0.14 ± 0.04	0.02 ± 0.01	0.01 ± 0.01	0.02 ± 0.01
Heart	0.39 ± 0.06	0.21 ± 0.04	0.15 ± 0.03	0.09 ± 0.02
(+lisinopril)	0.07 ± 0.03	0.03 ± 0.03	0.00 ± 0.01	0.03 ± 0.01
Lungs	15.20 ± 7.36	7.05 ± 1.97	5.91 ± 1.55	3.93 ± 1.17
(+lisinopril)	0.17 ± 0.06	0.03 ± 0.01	0.04 ± 0.06	0.02 ± 0.01
Liver	0.82 ± 0.13	0.59 ± 0.18	0.34 ± 0.06	0.17 ± 0.03
(+lisinopril)	2.46 ± 1.15	0.29 ± 0.07	0.15 ± 0.14	0.08 ± 0.01
Spleen	0.89 ± 0.12	0.65 ± 0.18	0.01 ± 0.06	0.19 ± 0.03
(+lisinopril)	0.06 ± 0.01	0.01 ± 0.01	0.00 ± 0.01	0.03 ± 0.01
Kidneys	1.21 ± 0.27	1.33 ± 0.46	1.30 ± 0.38	0.46 ± 0.14
(+lisinopril)	0.54 ± 0.08	0.16 ± 0.02	0.13 ± 0.02	0.08 ± 0.02
Large intestine	0.18 ± 0.05	0.17 ± 0.16	0.08 ± 0.02	0.10 ± 0.13
(+lisinopril)	0.04 ± 0.02	0.02 ± 0.00	0.03 ± 0.03	0.17 ± 0.32
Small intestine	1.86 ± 0.77	3.41 ± 1.18	6.02 ± 0.55	6.13 ± 1.36
(+lisinopril)	5.19 ± 2.16	6.99 ± 2.39	6.67 ± 1.94	11.36 ± 1.51
Skeletal muscle	0.41 ± 0.07	0.44 ± 0.16	0.36 ± 0.04	0.28 ± 0.02
(+lisinopril)	0.08 ± 0.05	0.02 ± 0.01	0.02 ± 0.01	0.04 ± 0.01
Adipose	0.24 ± 0.09	0.29 ± 0.09	0.29 ± 0.14	0.32 ± 0.06
(+lisinopril)	0.07 ± 0.02	0.01 ± 0.01	0.01 ± 0.02	0.06 ± 0.03

Data are mean ± SD.