Parameters Used in Decision Tree Modeling
| Limit for sensitivity analysis | |||
|---|---|---|---|
| Parameter | Baseline value | Lower | Upper |
| Prevalence of class I/II outcomes | 0.267 | 0.202 | 0.332 |
| Sensitivity of VEM/MRI for class I/II outcomes | 1.0 | 0.845 | 1.0 |
| Specificity of VEM/MRI for class I/II outcomes | 0.705 | 0.581 | 0.804 |
| Proportion of VEM/MRI indeterminate | 0.523 | 0.449 | 0.597 |
| Prevalence of class I/II outcomes if VEM/MRI indeterminate | 0.278 | 0.196 | 0.378 |
| Sensitivity of PET for class I/II outcomes if VEM/MRI indeterminate | 0.96 | 0.805 | 0.993 |
| Specificity of PET for class I/II outcomes if VEM/MRI indeterminate | 0.246 | 0.158 | 0.363 |
| Sensitivity of ictal SPECT for class I/II outcomes if VEM/MRI indeterminate | 0.783* | 0.664* | 0.869* |
| Specificity of ictal SPECT for class I/II outcomes if VEM/MRI indeterminate | 0.471* | 0.262* | 0.691* |
| Cost of VEM | $4,110 | NA | NA |
| Cost of MRI | $600 | NA | NA |
| Cost of ictal SPECT | $5,310 | NA | NA |
| Cost of PET | $918 | NA | NA |
| Cost of surgery | $25,691 | NA | NA |
| Cost savings after class I/II outcome | $440,000 | $0 | $700,000 |
↵* Data are based on Won et al. (36).
NA = not applied.