Uptake and Kinetics of 18F-AH111585 in Tumors and Normal Tissues
| Patient no. | Tumor region | ROI (tissue type) | SUVBSA × 10−3 (m2/mL) | SUVBW (g/mL) | Kimod × 10−5 (mL plasma /mL tissue[s]) | Kiclass × 10−5 (mL plasma /mL tissue[s]) | FRT* | MRT |
|---|---|---|---|---|---|---|---|---|
| 1 | 1 | SCF | 0.04 | 1.6 | n/a | n/a | n/a | n/a |
| Muscle | 0.02 | 1.0 | n/a | n/a | n/a | n/a | ||
| 2 | 2 | Breast tumor | 0.05 | 2.1 | 3.8 | 4.4 | 0.46 | 840.4 |
| Normal breast | 0.02 | 0.6 | 1.6 | 1.7 | 0.26 | 1,381.1 | ||
| 3 | 3 | Liver met 1 | 0.09 | 3.5 | 9.4 | 9.9 | 0.11 | 1,005.8 |
| 4 | Liver met 2 | 0.10 | 3.9 | 11.8 | 10.0 | 0.14 | 286.8 | |
| 5 | Liver met 3 | 0.08 | 3.1 | 9.4 | 9.6 | 0.26 | 1,216.6 | |
| 6 | Liver met 4 | 0.089 | 3.4 | 10.2 | 10.5 | 0.32 | 950.8 | |
| 7 | Liver met 5 | 0.04 | 1.4 | 3.7 | 3.9 | 0.08 | 361.9 | |
| 8 | Liver met 6 | 0.09 | 3.5 | 9.7 | 10.0 | 0.14 | 585.8 | |
| Normal liver | 0.11 | 4.5 | 9.8 | 10.8 | 0.05 | 91.5 | ||
| 4 | 9 | Liver met | 0.08 | 3.4 | 3.7 | 4.4 | 0.05 | 170.9 |
| Normal liver | 0.10 | 4.6 | 4.7 | 5.8 | 0.01 | 194.3 | ||
| 5 | 10 | Lung met 1 | 0.96 | 36.0 | 68.8 | 72.7 | 0.17 | 47.9 |
| 11 | Lung met 2 | 0.07 | 2.6 | 2.3 | 3.0 | 0.04 | 226.5 | |
| 12 | Lung met 3 | 0.05 | 2.0 | 4.0 | 4.2 | 0.15 | 714.3 | |
| 13 | Lung met 4 | 1.07 | 40.0 | 72.5 | 78.1 | 0.19 | 2,227.2 | |
| Normal lung | 0.02 | 0.9 | 1.0 | 1.3 | 0.05 | 333.5 | ||
| 6 | 14 | Lung met 1 | 0.18 | 6.8 | 27.5 | 28.7 | 0.25 | 2,415.3 |
| 15 | Lung met 2 | 0.17 | 6.2 | 21.8 | 23.8 | 0.23 | 2,032.6 | |
| 16 | Lung met 3 | 0.18 | 6.6 | 24.6 | 26.5 | 0.23 | 615.5 | |
| 17a | Lung met 4a | 0.14 | 5.2 | 22.1 | 21.1 | 0.26 | 2,761.2 | |
| 17b | Lung met 4b | 0.04 | 1.4 | 1.7 | 3.3 | 0.50 | 4,815.2 | |
| 18a | Lung met 5a | 0.14 | 5.2 | 17.4 | 19.2 | 0.32 | 1,458.2 | |
| 18b | Lung met 5b | 0.08 | 2.9 | 11.8 | 12.3 | 0.14 | 1,039.6 | |
| Normal lung | 0.03 | 1.0 | 2.4 | 3.0 | 0.10 | 450.7 | ||
| 7 | 19 | Liver met | 0.09 | 3.5 | 7.4 | 10.0 | 0.04 | 172.7 |
| Normal liver | 0.10 | 3.7 | 6.9 | 9.4 | 0.04 | 195.9 |
↵* FRT was calculated as ratio of unit impulse response function at 56.5 min to that at 1 min.
Data presented are analyses of radioligand uptake in 19 tumor regions from 18 CT-detectable lesions and 1 SCF. Whole or outer regions of tumor are indicated in standard font type, corresponding normal regions are in italics, and necrotic regions are in bold. In first patient, only SUV and area-under-curve calculations were performed because of concern about validity of ROI definition (not detected on CT). Met = metastasis; n/a = not applicable.