Direct Comparison of Estimated Input Functions
| Input function | Species | AUC (MBq·min/mL) | AUC error (%) | RMSE (MBq/mL) |
|---|---|---|---|---|
| Measured | Rat | 11.6 ± 3.7 | ||
| IDIF, no correction | Rat | 25.0 ± 9.4 | 120.7 ± 56.2 | 0.1721 ± 0.0929 |
| MCIF, 0-sample | Rat | 11.9 ± 3.8 | 5.3 ± 19.0 | 0.0391 ± 0.0140 |
| MCIF, 1-sample | Rat | 11.2 ± 3.7 | −2.3 ± 14.8 | 0.0384 ± 0.0165 |
| Measured | Mouse | 4.0 ± 1.4 | ||
| IDIF, no correction | Mouse | 20.4 ± 11.6 | 412.8 ± 234.8 | 0.2849 ± 0.1805 |
| MCIF, 0-sample | Mouse | 4.0 ± 1.7 | 4.3 ± 25.5 | 0.0370 ± 0.0176 |
| MCIF, 1-sample | Mouse | 3.9 ± 1.5 | −1.7 ± 21.0 | 0.0345 ± 0.0151 |
AUC error is calculated by (AUCest − AUCmea)/AUCmea·100. Values are expressed as mean ± SD.