TABLE 1

Initial Values and Bounds for Parameter Estimation to Obtain the MCIF

Parameter	k_{1 (1/min)}	k_{2 (1/min)}	k_{3 (1/min)}	k_{4 (1/min)}					τ _(min)	A_{1 (MBq/min/mL)}	A_{2 (MBq/mL)}	A_{3 (MBq/mL)}	L_{1 (1/min)}	L_{2 (1/min)}	L_{3 (1/min)}	w₁	w₂	w₃
Rat
Initial value	0.5	1	0.1	0.001	0.9	0.95	0.4	0.4	0	18.5	0.185	0.185	−7	−0.1	−0.015	1	1	0.1
Upper bound	2	2	0.5	0.01	1	1	0.6	0.6	0.1	111	0.74	0.555	−5	−0.05	−0.01	3	3	0.1
Lower bound	0	0	0	0	0.7	0.7	0	0	0	0	0	0	−20	−0.5	−0.02	0	0	0.05
Mouse pretreated with insulin
Initial value	0.01	0.01	0.001	0.001	0.9	0.95	0.4	0.4	0	111	0.296	0.259	−27	−0.55	−0.04	1	1	0.1
Upper bound	0.5	0.5	0.25	0.001	1	1	0.6	0.6	0.2	185	0.333	0.259	−17	−0.1	0	3	3	0.1
Lower bound	0	0	0	0	0.7	0.7	0	0	0	29.6	0.037	0.037	−38	−2	−0.04	0	0	0.05
Mouse untreated
Initial value	0.01	0.01	0.001	0.001	0.9	0.95	0.4	0.4	0	111	0.296	0.259	−27	−0.55	−0.04	1	1	0.1
Upper bound	0.5	0.5	0.25	0.001	1	1	0.6	0.6	0.2	185	0.333	0.259	−17	−0.1	0	3	3	0.1
Lower bound	0	0	0	0	0.7	0.7	0	0	0	29.6	0.037	0.037	−38	−2	−0.04	0	0	0.05