Published Clinical Applications of 18F-DOPA PET in Hyperinsulinism
| Disease type | Total no. of patients | No. of patients with indicated disease form | No. of patients undergoing surgery | No. (%) of patients for whom 18F-DOPA PET results (vs. surgery) were correct | |||||
|---|---|---|---|---|---|---|---|---|---|
| Authors | Year | Reference | Focal | Diffuse | Other findings | ||||
| Ribeiro et al. | 2005 | 70 | NHI | 15 | 5 | 10 | 9 (5 with focal form + 4 with diffuse form) | 9 (100) | |
| Otonkoski et al. | 2006 | 71 | NHI | 14 | 5 | 9 | 9 (5 with focal form + 4 with diffuse form) | 9 (100) | SUV of >50% for rest of pancreas |
| de Lonlay et al. | 2006 | 72 | NHI | 7 | 3 | 4 | ICH verification, patients from study of Ribeiro et al. (70)? | ||
| Kauhanen et al. | 2007 | 73 | Adult insulinoma | 10 | 8 | 2 | 9 | 9 (100) | Sensitivity of PET (90%) was greater than those of CT (30%) and MRI (40%); in 50% of patients, PET results had impact on surgery |
| Hussain et al. | 2006 | 74 | NHI | 1 | 1 | PET detected focal ectopic lesion after unsuccessful earlier surgeries | |||
| Hardy et al. | 2007 | 75 | NHI | 24 | 12 | 12 | 24 | 23 (96) | All focal lesions were correctly localized |
NHI = neonatal hyperinsulinism; ICH = immunohistochemistry.