Effect of P-gp Inhibitors on Plasma Free Fraction in Monkey
| Plasma free fraction | |||
|---|---|---|---|
| P-gp inhibitor (mg/kg) | Baseline | P-gp inhibition | Percentage difference |
| DCPQ (1.0) | 5.1 ± 0.2 | 5.7 ± 0.3 | +12 |
| DCPQ (3.0) | 1.6 ± 0.6 | 1.4 ± 0.5 | −13 |
| DCPQ (8.0) | 4.8 ± 1.7 | 4.4 ± 1.4 | −8.3 |
| Tariquidar (8.0) | 1.64 ± 0.56 | 1.71 ± 0.5 | +4.3 |
Values are mean ± SD of at least 3 observations. Percentage difference was calculated relative to baseline.