Biodistribution | 1 h after injection | 4 h after injection | 24 h after injection |
---|---|---|---|
Blood | 0.29 ± 0.01 | 0.21 ± 0.03 | 0.15 ± 0.02 |
Lung | 1.81 ± 0.12 | 2.07 ± 0.33 | 1.43 ± 0.19 |
Spleen | 0.82 ± 0.33 | 0.72 ± 0.27 | 0.68 ± 0.40 |
Kidneys | 73.68 ± 16.23 | 85.61 ± 11.90 | 81.23 ± 6.34 |
Stomach | 2.91 ± 0.03 | 3.21 ± 0.61 | 2.15 ± 0.40 |
Intestines | 0.80 ± 0.09 | 1.43 ± 0.39 | 0.76 ± 0.12 |
Liver | 9.97 ± 3.28 | 7.32 ± 1.08 | 4.41 ± 1.26 |
Muscle | 1.65 ± 0.16 | 1.83 ± 0.06 | 1.35 ± 0.29 |
Bone | 1.29 ± 0.08 | 1.51 ± 0.28 | 1.12 ± 0.32 |
Salivary glands | 14.04 ± 3.03 | 12.18 ± 1.23 | 8.70 ± 1.56 |
Tumor | 8.74 ± 0.89 | 9.79 ± 3.21 | 7.13 ± 2.37 |
Tumor-to-blood | 29.55 ± 2.62 | 47.04 ± 12.59 | 49.96 ± 20.82 |
Tumor-to-liver | 1.02 ± 0.33 | 1.34 ± 0.54 | 1.81 ± 0.98 |
Tumor-to-kidney | 0.12 ± 0.02 | 0.11 ± 0.04 | 0.09 ± 0.03 |
Pemetrexed* | Pemetrexed* | Pemetrexed* | |
Biodistribution | 1 h after injection | 4 h after injection | 24 h after injection |
Blood | 0.29 ± 0.07 | 0.21 ± 0.11 | 0.09 ± 0.02 |
Lung | 1.35 ± 0.13 | 1.33 ± 0.58 | 0.92 ± 0.36 |
Spleen | 0.39 ± 0.05 | 0.47 ± 0.05 | 0.33 ± 0.14 |
Kidneys | 21.59 ± 2.18 | 22.56 ± 1.95 | 19.43 ± 5.13 |
Stomach | 2.31 ± 0.34 | 2.29 ± 0.73 | 1.40 ± 0.11 |
Intestines | 0.39 ± 0.09 | 0.54 ± 0.22 | 0.51 ± 0.28 |
Liver | 7.87 ± 0.93 | 4.44 ± 1.37 | 2.09 ± 0.26 |
Muscle | 1.37 ± 0.51 | 1.25 ± 0.22 | 0.60 ± 0.10 |
Bone | 0.74 ± 0.48 | 0.77 ± 0.12 | 0.49 ± 0.10 |
Salivary glands | 8.47 ± 1.62 | 7.68 ± 0.79 | 4.11 ± 0.53 |
Tumor | 8.13 ± 0.96 | 11.01 ± 1.76 | 7.87 ± 1.13 |
Tumor-to-blood | 29.67 ± 9.41 | 61.61 ± 25.29 | 98.39 ± 9.60 |
Tumor-to-liver | 1.05 ± 0.20 | 2.68 ± 1.00 | 3.71 ± 0.87 |
Tumor-to-kidney | 0.38 ± 0.07 | 0.49 ± 0.09 | 0.45 ± 0.13 |
↵* 400 μg, injected 1 h before injection of radiotracer.