TABLE 1

Biodistribution of ¹¹¹In-DTPA-Folate in IGROV-1 Tumor-Bearing Female Nude Mice

Biodistribution	1 h after injection	4 h after injection	24 h after injection
Blood	0.29 ± 0.01	0.21 ± 0.03	0.15 ± 0.02
Lung	1.81 ± 0.12	2.07 ± 0.33	1.43 ± 0.19
Spleen	0.82 ± 0.33	0.72 ± 0.27	0.68 ± 0.40
Kidneys	73.68 ± 16.23	85.61 ± 11.90	81.23 ± 6.34
Stomach	2.91 ± 0.03	3.21 ± 0.61	2.15 ± 0.40
Intestines	0.80 ± 0.09	1.43 ± 0.39	0.76 ± 0.12
Liver	9.97 ± 3.28	7.32 ± 1.08	4.41 ± 1.26
Muscle	1.65 ± 0.16	1.83 ± 0.06	1.35 ± 0.29
Bone	1.29 ± 0.08	1.51 ± 0.28	1.12 ± 0.32
Salivary glands	14.04 ± 3.03	12.18 ± 1.23	8.70 ± 1.56
Tumor	8.74 ± 0.89	9.79 ± 3.21	7.13 ± 2.37
Tumor-to-blood	29.55 ± 2.62	47.04 ± 12.59	49.96 ± 20.82
Tumor-to-liver	1.02 ± 0.33	1.34 ± 0.54	1.81 ± 0.98
Tumor-to-kidney	0.12 ± 0.02	0.11 ± 0.04	0.09 ± 0.03
	Pemetrexed^*	Pemetrexed^*	Pemetrexed^*
Biodistribution	1 h after injection	4 h after injection	24 h after injection
Blood	0.29 ± 0.07	0.21 ± 0.11	0.09 ± 0.02
Lung	1.35 ± 0.13	1.33 ± 0.58	0.92 ± 0.36
Spleen	0.39 ± 0.05	0.47 ± 0.05	0.33 ± 0.14
Kidneys	21.59 ± 2.18	22.56 ± 1.95	19.43 ± 5.13
Stomach	2.31 ± 0.34	2.29 ± 0.73	1.40 ± 0.11
Intestines	0.39 ± 0.09	0.54 ± 0.22	0.51 ± 0.28
Liver	7.87 ± 0.93	4.44 ± 1.37	2.09 ± 0.26
Muscle	1.37 ± 0.51	1.25 ± 0.22	0.60 ± 0.10
Bone	0.74 ± 0.48	0.77 ± 0.12	0.49 ± 0.10
Salivary glands	8.47 ± 1.62	7.68 ± 0.79	4.11 ± 0.53
Tumor	8.13 ± 0.96	11.01 ± 1.76	7.87 ± 1.13
Tumor-to-blood	29.67 ± 9.41	61.61 ± 25.29	98.39 ± 9.60
Tumor-to-liver	1.05 ± 0.20	2.68 ± 1.00	3.71 ± 0.87
Tumor-to-kidney	0.38 ± 0.07	0.49 ± 0.09	0.45 ± 0.13