Biodistribution of 111In-DOTA-Anti-bcl-2-PNA-Tyr3-Octreotate in SCID Mice Bearing Mec-1 SLL Xenografts (n = 5)
| Biodistribution (%ID/g ± SD) | ||||
|---|---|---|---|---|
| Tissue | 1 h | 4 h | 24 h | 48 h |
| Blood | 2.56 ± 0.21 | 2.38 ± 0.46 | 0.57 ± 0.12 | 0.19 ± 0.02 |
| Lung | 6.06 ± 1.20 | 2.56 ± 0.31 | 1.36 ± 0.29 | 1.97 ± 0.04 |
| Liver | 12.6 ± 2.03 | 6.70 ± 1.67 | 6.17 ± 1.36 | 6.12 ± 1.50 |
| Spleen | 2.75 ± 0.51 | 1.34 ± 0.04 | 1.36 ± 0.28 | 1.05 ± 0.06 |
| Kidney | 77.1 ± 16.5 | 129.4 ± 25.7 | 70.2 ± 5.73 | 32.8 ± 6.38 |
| Bladder | 1.71 ± 0.93 | 1.34 ± 0.29 | 0.84 ± 0.18 | 0.71 ± 0.18 |
| Muscle | 0.32 ± 0.02 | 0.20 ± 0.04 | 0.12 ± 0.02 | 0.12 ± 0.02 |
| Fat | 0.21 ± 0.04 | 0.29 ± 0.06 | 0.23 ± 0.05 | 0.16 ± 0.03 |
| Heart | 0.93 ± 0.12 | 0.99 ± 0.13 | 0.61 ± 0.12 | 0.34 ± 0.04 |
| Bone | 0.82 ± 0.13 | 0.41 ± 0.05 | 0.42 ± 0.08 | 0.35 ± 0.09 |
| Stomach | 2.12 ± 0.70 | 2.33 ± 0.79 | 1.02 ± 0.18 | 0.51 ± 0.14 |
| Small intestine | 1.24 ± 0.19 | 0.79 ± 0.21 | 0.32 ± 0.04 | 0.24 ± 0.04 |
| Large intestine | 1.19 ± 0.12 | 2.26 ± 0.47 | 0.48 ± 0.07 | 0.41 ± 0.10 |
| Tumor | 1.32 ± 0.08 | 1.40 ± 0.32 | 1.02 ± 0.18 | 0.88 ± 0.22 |