Biodistribution of 111In-DOTA-Tyr3-Octreotate in SCID Mice Bearing Mec-1 SLL Xenografts (n = 5)
| Biodistribution (%ID/g ± SD) | |||
|---|---|---|---|
| Tissue | 1 h | 4 h | 24 h |
| Blood | 0.31 ± 0.07 | 0.06 ± 0.01 | 0.02 ± 0.003 |
| Lung | 8.27 ± 1.88 | 6.87 ± 0.54 | 4.12 ± 0.84 |
| Liver | 0.32 ± 0.07 | 0.29 ± 0.06 | 0.20 ± 0.04 |
| Spleen | 0.63 ± 0.14 | 0.48 ± 0.10 | 0.44 ± 0.10 |
| Kidney | 11.4 ± 1.70 | 11.0 ± 1.46 | 6.39 ± 0.73 |
| Bladder | 5.18 ± 1.51 | 0.59 ± 0.21 | 0.22 ± 0.03 |
| Muscle | 0.04 ± 0.01 | 0.02 ± 0.002 | 0.01 ± 0.001 |
| Fat | 0.08 ± 0.026 | 0.03 ± 0.008 | 0.01 ± 0.003 |
| Heart | 0.26 ± 0.03 | 0.12 ± 0.02 | 0.07 ± 0.02 |
| Bone | 0.52 ± 0.10 | 0.57 ± 0.10 | 0.22 ± 0.05 |
| Stomach | 5.80 ± 1.47 | 5.14 ± 1.26 | 1.87 ± 0.31 |
| Small intestine | 1.70 ± 0.31 | 0.96 ± 0.009 | 0.40 ± 0.06 |
| Large intestine | 2.06 ± 0.33 | 5.25 ± 0.84 | 1.09 ± 0.25 |
| Tumor | 3.24 ± 0.77 | 3.24 ± 0.85 | 1.49 ± 0.29 |