Mean ± SD | |||||
---|---|---|---|---|---|
Mouse | K1, mL/min/g (18F-FLT transport from blood to tissue) | k2, min−1 (18F-FLT efflux from tissue to blood) | k3, min−1 (18F-FLT phosphorylation) (retention) | k4, min−1 (18F-FLT efflux) (dephosphorylation or nucleoside transport) | KFLT, mL/min/g (18F-FLT metabolic flux) |
Tumor bearing | |||||
1 | 0.296 ± 0.003 | 0.512 ± 0.006 | 0.205 ± 0.007 | 0.384 ± 0.010 | 0.085 ± 0.003 |
2 | 1.120 ± 0.030 | 0.724 ± 0.021 | 0.090 ± 0.020 | 0.540 ± 1.240 | 0.124 ± 0.029 |
3 | 0.139 ± 0.004 | 0.261 ± 0.059 | 0.138 ± 0.008 | 0.260 ± 0.011 | 0.048 ± 0.005 |
4 | 0.558 ± 0.023 | 0.258 ± 0.001 | 0.139 ± 0.013 | 0.148 ± 0.017 | 0.195 ± 0.022 |
5 | 0.504 ± 0.025 | 0.192 ± 0.011 | 0.110 ± 0.016 | 0.190 ± 0.024 | 0.184 ± 0.031 |
6 | 0.352 ± 0.005 | 0.376 ± 0.009 | 0.343 ± 0.010 | 0.348 ± 0.010 | 0.168 ± 0.008 |
7 | 0.313 ± 0.009 | 0.475 ± 0.015 | 0.295 ± 0.014 | 0.159 ± 0.007 | 0.120 ± 0.009 |
8 | 0.243 ± 0.001 | 0.202 ± 0.001 | 0.270 ± 0.027 | 0.255 ± 0.002 | 0.139 ± 0.019 |
9 | 0.401 ± 0.013 | 0.202 ± 0.006 | 0.174 ± 0.014 | 0.246 ± 0.020 | 0.186 ± 0.019 |
10 | 0.385 ± 0.008 | 0.411 ± 0.009 | 0.502 ± 0.002 | 0.343 ± 0.014 | 0.212 ± 0.006 |
Mean ± SD | 0.431 ± 0.012 | 0.363 ± 0.014 | 0.226 ± 0.013 | 0.287 ± 0.134 | 0.146 ± 0.015 |
Control | |||||
1 | 0.100 ± 0.003 | 0.137 ± 0.004 | 5.0 × 10−7 ± 5.0 × 10−10 | 0.100 ± 0.0001 | 3.65 × 10−7 ± 3.75 × 10−10 |
2 | 0.600 ± 0.004 | 0.090 ± 0.006 | 0 ± 0 | 0 ± 0 | 0 ± 0 |
3 | 0.888 ± 0.040 | 0.123 ± 0.006 | 0 ± 0 | 0 ± 0 | 0 ± 0 |
4 | 0.244 ± 0.009 | 0.164 ± 0.011 | 0 ± 0 | 0 ± 0 | 0 ± 0 |
Mean ± SD | 0.458 ± 0.014 | 0.128 ± 0.007 | ∼0 | 0.025 ± 00002 | ∼0 |
P* | NS | <0.02 | <0.005 | <0.001 | <0.0002 |
↵* For comparison with control mice. NS = not significant.