Biodistribution of [99mTc]Demobesin 1 in Human PC3 Xenograft–Bearing SCID Mice at 1, 4, and 24 Hours After Injection
| [99mTc]Demobesin 1 | |||
|---|---|---|---|
| Organ | 1 h | 4 h | 24 h |
| Blood | 1.36 ± 0.09 | 0.24 ± 0.06 | 0.07 ± 0.01 |
| Liver | 9.62 ± 0.97 | 6.62 ± 0.66 | 2.61 ± 0.16 |
| Heart | 0.76 ± 0.08 | 0.19 ± 0.03 | 0.14 ± 0.03 |
| Kidneys | 8.08 ± 0.65 | 4.33 ± 0.44 | 1.02 ± 0.18 |
| Stomach | 2.10 ± 0.30 | 2.12 ± 0.48 | 1.37 ± 0.98 |
| Intestines | 10.27 ± 0.55 | 10.36 ± 0.46 | 1.35 ± 0.51 |
| Blocked intestines*† | ND | 10.72 ± 0.85‡ | ND |
| Spleen | 1.66 ± 0.25 | 1.68 ± 0.94 | 0.90 ± 0.17 |
| Muscle | 0.24 ± 0.02 | 0.06 ± 0.01 | 0.04 ± 0.01 |
| Lungs | 1.37 ± 0.12 | 0.38 ± 0.05 | 0.15 ± 0.02 |
| Pancreas | 104.39 ± 3.59 | 49.82 ± 6.69 | 1.29 ± 0.46 |
| Blocked pancreas*† | ND | 6.48 ± 0.20§ | ND |
| PC3 tumor | 24.61 ± 1.98 | 22.66 ± 2.20 | 5.38 ± 0.72 |
| Blocked tumor*† | ND | 5.19 ± 1.35§ | ND |
| Tumor/blood | 18.10 | 94.42 | 76.86 |
| Tumor/muscle | 102.54 | 377.67 | 134.50 |
| Tumor/liver | 2.60 | 3.42 | 2.06 |
| Tumor/kidney | 3.00 | 5.23 | 5.27 |
↵* In vivo blockade was achieved by coinjection of 100 μg [Tyr4]bombesin.
↵† Statistical analysis was performed using the Student t test with P values indicating extremely significant difference (§P < 0.001) vs. unblocked. ‡P > 0.5 (not significant).
ND = not determined.
Data are expressed as ID%/g (percentage injected dose per gram) and are presented as mean ± SD (n = 4).