Biodistribution Data of 99mTc-His-Folate in Athymic Nude Male Mice Bearing KB Tumor Xenografts
| %ID/g (mean ± SD) | ||||
|---|---|---|---|---|
| Tissue or ratio | 1 h after injection | 4 h after injection | 24 h after injection | 4 h after injection* |
| Blood | 0.18 ± 0.10 | 0.12 ± 0.02 | 0.02 ± 0.01 | <0.01 |
| Heart | 3.60 ± 0.53 | 1.16 ± 0.36 | 0.14 ± 0.07 | <0.01 |
| Lung | 1.04 ± 0.12 | 0.69 ± 0.09 | 0.16 ± 0.07 | <0.01 |
| Spleen | 0.37 ± 0.22 | 0.30 ± 0.04 | 0.05 ± 0.01 | <0.01 |
| Kidneys | 23.96 ± 10.11 | 24.56 ± 3.17 | 6.70 ± 1.12 | 0.30 ± 0.31 |
| Stomach | 1.71 ± 0.12 | 1.03 ± 0.22 | 0.15 ± 0.02 | 0.02 ± 0.02 |
| Intestines | 3.84 ± 2.23 | 1.51 ± 0.29 | 0.18 ± 0.14 | 0.17 ± 0.06 |
| Liver | 9.73 ± 1.32 | 3.83 ± 1.49 | 0.44 ± 0.31 | 0.20 ± 0.03 |
| Muscle | 1.56 ± 0.07 | 1.09 ± 0.26 | 0.19 ± 0.03 | <0.01 |
| Bone | 0.77 ± 0.07 | 0.58 ± 0.20 | 0.06 ± 0.01 | <0.01 |
| Salivary glands | 6.52 ± 1.04 | 5.72 ± 0.63 | 1.58 ± 0.69 | <0.01 |
| Tumor | 2.63 ± 0.48 | 4.29 ± 0.67 | 3.51 ± 0.37 | 0.06 ± 0.01 |
| Tumor-to-blood | 18.56 ± 10.47 | 38.00 ± 8.33 | 184.23 ± 65.88 | |
| Tumor-to-liver | 0.30 ± 0.06 | 1.19 ± 0.47 | 10.99 ± 5.60 | |
| Tumor-to-kidney | 0.12 ± 0.05 | 0.18 ± 0.03 | 0.53 ± 0.10 | |
↵* Coinjection of excess folic acid.
n = 3 mice.