Three-Compartment, 2-Tissue Model with 3 Parameter Estimates, k1–k3, Influx Rate Constant K, and Distribution Volume Vd
| Type | Primary Cancer | Recurrent cancer | P | BPH |
|---|---|---|---|---|
| n | 10 | 10 | 2 | |
| k1 | 0.419 ± 0.136 | 0.208 ± 0.073 | <0.001 | 0.339 ± 0.050 |
| k2 | 0.218 ± 0.074 | 0.202 ± 0.124 | NS | 0.122 ± 0.066 |
| k3 | 0.120 ± 0.026 | 0.140 ± 0.054 | NS | 0.066 ± 0.058 |
| K | 0.152 ± 0.051 | 0.086 ± 0.017 | <0.01 | 0.110 ± 0.049 |
| Vd | 1.25 ± 0.32 | 0.69 ± 0.27 | <0.001 | 2.19 ± 1.18 |
| Patlak K | 0.137 ± 0.062 | 0.079 ± 0.035 | 0.02 | 0.121 ± 0.048 |
| Patlak Vd | 1.95 ± 1.67 | 1.00 ± 1.27 | NS | 2.49 ± 1.22 |
| SUV-early | 3.80 ± 0.99 | 1.83 ± 0.40 | <0.001 | 3.55 ± 0.60 |
| SUV-late | 3.84 ± 1.07 | 1.91 ± 0.34 | <0.001 | 3.35 ± 0.24 |
NS = not significant.
Patlak plot results are given, as well. Results are expressed as mean ± 1 SD for 3 different tissue types. 1-11C-Acetate uptake at early (6–10 min) and late (15–20 min) time points is presented in SUVs. P denotes significance level by comparison of primary vs. recurrent cancers.