TABLE 2

Average CBF, CBV, CMRO₂, and OEF Values (n = 8)

Parameter	CBF (mL/100 mL/min)			CBV (mL/100 mL)
Scan mode		3D PET			3D PET
Scatter correction	2D PET	No	HDE	2D PET	No	HDE
Pons	45 ± 10	44 ± 8	46 ± 11	3.0 ± 0.9	5.8 ± 1.1^*	3.4 ± 1.0^†
Cerebellum	59 ± 14	50 ± 9^*	68 ± 21^†	4.0 ± 0.7	5.6 ± 0.8^*	3.9 ± 1.1^†
Parahippocampal gyrus	44 ± 9	43 ± 6	47 ± 8	5.0 ± 0.6	6.6 ± 1.0^*	4.8 ± 0.9^†
Midbrain	44 ± 7	43 ± 6	45 ± 8	3.2 ± 0.6	6.0 ± 0.8^*	3.7 ± 0.8^†
Putamen	64 ± 22	51 ± 8	64 ± 13^†	2.7 ± 0.7	5.0 ± 0.6^*	2.9 ± 0.4^†
Temporal cortex	52 ± 12	40 ± 6^*	51 ± 9^†	3.7 ± 0.5	4.7 ± 0.5^*	3.6 ± 0.4^†
Frontal cortex	50 ± 10	37 ± 4^*	50 ± 8^†	3.4 ± 0.3	4.0 ± 0.6^*	3.1 ± 0.6^†
Anterior cingulate	56 ± 17	41 ± 8^*	57 ± 17^†	3.8 ± 0.6	4.8 ± 0.5^*	3.7 ± 0.6^†
Thalamus	56 ± 14	50 ± 7	59 ± 11^†	3.3 ± 0.5	5.5 ± 0.7^*	3.4 ± 0.5^†
Occipital cortex	58 ± 15	45 ± 7^*	58 ± 11^†	4.5 ± 0.5	5.7 ± 0.9^*	4.7 ± 0.7^†
Posterior cingulate	58 ± 15	48 ± 7^*	61 ± 13^†	3.8 ± 0.4	5.0 ± 0.4^*	3.6 ± 0.6^†
Parietal cortex	49 ± 7	38 ± 5^*	51 ± 10^†	3.3 ± 0.4	4.1 ± 0.5^*	3.2 ± 0.3^†
Centrum semiovale	19 ± 3	23 ± 2^*	20 ± 2^†	1.7 ± 0.3	3.7 ± 0.5^*	1.8 ± 0.4^†
Gray matter total	53 ± 12	44 ± 6^*	55 ± 11^†	3.6 ± 0.3	5.2 ± 0.6^*	3.7 ± 0.5^†
Gray–to–white matter ratio	2.8 ± 0.3	1.9 ± 0.2^*	2.7 ± 0.4^†	2.2 ± 0.3	1.4 ± 0.1^*	2.1 ± 0.3^†
Parameter	CMRO₂ (mL/100 mL/min)			OEF
Scan mode		3D PET			3D PET
Scatter correction	2D PET	No	HDE	2D PET	No	HDE
Pons	2.7 ± 0.5	3.1 ± 0.5^*	2.7 ± 0.6	0.31 ± 0.05	0.36 ± 0.06^*	0.31 ± 0.07^†
Cerebellum	3.8 ± 0.7	3.5 ± 0.4	4.4 ± 1.1^†	0.34 ± 0.06	0.37 ± 0.06	0.35 ± 0.07^†
Parahippocampal gyrus	2.3 ± 0.3	3.1 ± 0.4^*	2.9 ± 0.5^*	0.28 ± 0.05	0.37 ± 0.04^*	0.32 ± 0.05^†
Midbrain	2.8 ± 0.5	3.4 ± 0.3^*	3.1 ± 0.4^†	0.33 ± 0.06	0.41 ± 0.05^*	0.37 ± 0.06^*^†
Putamen	4.7 ± 0.9	4.1 ± 0.7	4.9 ± 1.1^†	0.40 ± 0.09	0.42 ± 0.08	0.40 ± 0.09
Temporal cortex	3.7 ± 0.5	3.2 ± 0.4^*	3.9 ± 0.6^†	0.38 ± 0.07	0.42 ± 0.07	0.40 ± 0.07^†
Frontal cortex	3.3 ± 0.5	2.7 ± 0.4^*	3.4 ± 0.6^†	0.35 ± 0.05	0.39 ± 0.05^*	0.35 ± 0.06^†
Anterior cingulate	3.5 ± 0.8	2.9 ± 0.5^*	3.5 ± 0.9^†	0.34 ± 0.07	0.37 ± 0.06^*	0.33 ± 0.06^†
Thalamus	3.7 ± 0.5	3.5 ± 0.5	3.8 ± 0.8	0.36 ± 0.06	0.37 ± 0.05	0.34 ± 0.05^†
Occipital cortex	4.3 ± 0.8	3.5 ± 0.3^*	4.3 ± 0.7^†	0.40 ± 0.06	0.40 ± 0.05	0.39 ± 0.05
Posterior cingulate	4.0 ± 0.6	3.6 ± 0.6^*	4.4 ± 0.9^†	0.37 ± 0.07	0.39 ± 0.06	0.38 ± 0.07
Parietal cortex	3.7 ± 0.5	3.0 ± 0.4^*	3.9 ± 0.8^†	0.39 ± 0.06	0.40 ± 0.05	0.40 ± 0.05
Centrum semiovale	1.4 ± 0.2	1.7 ± 0.2^*	1.5 ± 0.3^†	0.41 ± 0.08	0.40 ± 0.06	0.39 ± 0.09
Gray matter total	3.5 ± 0.5	3.3 ± 0.4	3.8 ± 0.7^†	0.35 ± 0.06	0.39 ± 0.05^*	0.36 ± 0.06^†
Gray–to–white matter ratio	2.5 ± 0.2	1.9 ± 0.2^*	2.6 ± 0.5^†	0.87 ± 0.04	0.98 ± 0.07^*	0.94 ± 0.10

↵* Significant difference vs. 2D PET value.
↵† Significant difference vs. uncorrected 3D PET value.
Gray matter total = values averaged over 12 gray matter regions; Gray–to–white matter ratio = ratio of gray matter total to white matter value of the centrum semiovale.
Values are shown as mean ± SD. Differences between studies were examined by paired t test (P < 0.05) with Bonferroni correction for multiple comparisons.