Kinetic Parameters for 18F-FLT PET in Mice Implanted with A431 and LLC Tumors
| Cell line | Method | K1 | K1/k2 | k3 | k4 | Vb | DVm | KFLT |
|---|---|---|---|---|---|---|---|---|
| A431 (n = 7) | 3C5P | 0.227 (24.6) | 1.860 (51.5) | 0.123 (32.4) | 0.011 (27.6) | 0.033 (58.5) | 20.64 (46.6) | 0.103 (14.2) |
| 3C4P | 0.163 (17.0) | 6.349 (35.2) | 0.021 (38.7) | — | 0.055 (60.2) | — | 0.068 (18.1) | |
| 2C3P | 0.134 (14.4) | 17.52 (34.7) | — | — | 0.087 (57.7) | — | — | |
| GPGA | — | — | — | — | — | — | 0.076 (15.6) | |
| LLC (n = 10) | 3C5P | 0.169 (26.9) | 0.656 (14.2) | 0.017 (29.3) | 0.015 (22.1) | 0.044 (45.6) | 0.793 (39.9) | 0.010 (20.3) |
| 3C4P | 0.133 (28.5) | 0.788 (9.4) | 0.006 (30.3) | — | 0.059 (39.0) | — | 0.005 (34.2) | |
| 2C3P | 0.063 (24.5) | 1.156 (17.7) | — | — | 0.093 (15.9) | — | — | |
| GPGA | — | — | — | — | — | — | 0.003 (34.9) |
3C5P = 3 compartments and 5 parameters (K1, K1/k2, k3, k4, and Vb); 3C4P = 3 compartments and 4 parameters (K1, K1/k2, k3, and Vb), with k4 fixed at zero; 2C3P = 2 compartments and 3 parameters (K1, K1/k2, and Vb); GPGA = Gjedde–Patlak graphic analysis.
Data are presented as means (CVs).