TABLE 2

Impact of PET on Intended Management by Cancer Type^*

Cancer type	No. of scans	% of cases with change in management^†	95% CI	Odds ratio for change in management compared with that for other cancers^‡	95% CI	Frequency of other imaging as plan before PET (%)	Imaging-adjusted impact (%)^§	95% CI
Prostate	5,309	35.1	33.8–36.4	0.86^‖	0.81–0.92	39.9	15.0	14.1–16.0
Ovary	4,509	41.4	40.0–42.9	1.17^‖	1.10–1.25	52.1	16.2	15.1–17.3
Bladder	3,578	37.9	36.3–39.5	0.99^¶	0.93–1.07	45.1	15.4	14.2–16.6
Pancreas	3,314	39.0	37.3–40.6	1.04^¶	0.97–1.12	42.7	14.8	13.6–16.1
Stomach	3,025	36.9	35.2–38.6	0.95^¶	0.88–1.03	45.2	14.5	13.2–15.7
Small cell lung	2,983	41.2	39.5–43.0	1.16^#	1.07–1.25	49.7	13.1	11.9–14.3
Kidney	2,877	35.8	34.0–37.6	0.90^¶	0.83–0.98	48.9	16.0	14.7–17.4
Uterus	2,869	36.5	34.7–38.2	0.93^¶	0.86–1.01	47.6	15.1	13.8–16.4
Myeloma	1,784	48.7	46.3–51.0	1.58^‖	1.43–1.73	61.3	11.5	10.0–13.0
Connective tissue	1,350	36.4	33.8–38.9	0.93^¶	0.83–1.04	49.9	13.6	11.8–15.5
Nonmelanoma skin	1,057	31.4	28.6–34.2	0.74^#	0.65–0.84	49.8	9.6	7.9–11.4
Liver and intrahepatic bile ducts	1,038	42.9	39.9–45.9	1.23^¶	1.08–1.39	44.3	15.8	13.6–18.0
Cervix	984	32.7	29.8–35.7	0.79^#	0.69–0.90	48.4	11.9	9.9–13.9
Gallbladder	806	39.7	36.3–43.1	1.07^¶	0.93–1.24	43.8	15.4	12.9–17.9
Other female genital	709	37.1	33.5–40.7	0.96^¶	0.82–1.12	41.9	13.0	10.5–15.4
Thyroid	629	35.6	31.9–39.4	0.90^¶	0.76–1.06	53.6	13.4	10.7–16.0
All other	4,042	36.6	35.1–38.1	0.93^¶	0.87–1.00	49.2	15.7	14.5–16.8
Total	40,863	38.0	37.6–38.5	NA	NA	47.3	14.7	14.3–15.0

↵* Specific cancer types are listed when there were at least 500 cases for initial staging, restaging, and detection of suspected recurrence combined.
↵† Defined as change from treatment to nontreatment or as change from nontreatment to treatment.
↵‡ Odds ratio of 1 implies that chance of changing management is equal between an individual cancer and all other cancer groups. Odds ratio <1 implies that chance of changing management is lower for the individual cancer than for all the others. Odds ratio >1 implies that chance of changing management is higher for an individual cancer than for all the others. NA = not applicable.
↵§ No benefit from PET was assumed for cases with imaging plan before PET.
↵‖ Bonferroni-adjusted χ² P value for chance of change in management was <10⁻⁴.
↵¶ Bonferroni-adjusted χ² P value for chance of change in management was between 0.01 and 1.0.
↵# Bonferroni-adjusted χ² P value for chance of change in management was between 0.0001 and 0.01.