Statistical Findings for Prediction of Elevated OEF
| PET parameter | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Accuracy |
|---|---|---|---|---|---|
| CVR < 14% | 100 (17/17) | 51.3 (58/113) | 26.6 (17/64) | 100 (58/58) | 0.58 |
| Type 3 | 100 (17/17) | 83.2 (94/113) | 47.2 (17/36) | 100 (94/94) | 0.85 |
| CBV > 4.4 mL/100 g | 17.6 (3/17) | 92.9 (105/113) | 27.3 (3/11) | 88.2 (105/119) | 0.83 |
| CMRO2 > 2.7 mL/100 g/min | 23.5 (4/17) | 72.6 (82/113) | 11.4 (4/35) | 86.3 (82/95) | 0.66 |
| MTT > 0.12 min | 88.2 (15/17) | 84.1 (95/113) | 45.5 (15/33) | 97.9 (95/97) | 0.58 |
| Type 3 and CBV > 4.4 mL/100 g | 17.6 (3/17) | 100 (113/113) | 100 (3/3) | 89.0 (113/127) | 0.89 |
| Type 3 and CMRO2 > 2.7 mL/100 g/min | 23.5 (4/17) | 99.1 (112/113) | 80.0 (4/5) | 89.6 (112/125) | 0.89 |
| Type 3 and MTT > 0.12 min | 88.2 (15/17) | 97.3 (110/113) | 83.3 (15/18) | 98.2 (110/112) | 0.96 |
Values were rated as reduced when any value was less than mean − 2 SDs and rated as elevated when any value was more than mean + 2 SDs. On basis of our previous studies, CVR was judged as reduced when value was less than 14% (6,8,11).