Baseline Characteristics
| Characteristic | HCC, n = 99 | CCC, n = 13 |
|---|---|---|
| Age (y) | ||
| <50 | 29 (29.3) | 1 (7.7) |
| ≥50 | 70 (70.7) | 12 (92.3) |
| Sex | ||
| Male | 78 (78.8) | 10 (76.9) |
| Female | 21 (21.2) | 3 (23.1) |
| Etiology* | ||
| Hepatitis B | 79 (79.8) | 4 (30.8) |
| Hepatitis C | 8 (8.1) | 2 (15.4) |
| Alcohol | 8 (8.1) | 2 (15.4) |
| Other | 5 (5.0) | 5 (38.4) |
| Child–Pugh class | ||
| A | 89 (89.9) | 12 (92.3) |
| B | 10 (10.1) | 1 (7.7) |
| EGOG performance | ||
| 0 | 65 (65.7) | 8 (61.5) |
| 1 | 27 (27.2) | 3 (23.1) |
| 2 | 7 (7.1) | 2 (15.4) |
| Tumor size† (cm) | ||
| ≥1, <2 | 7 (7.8) | 0 (0) |
| ≥2, <5 | 42 (46.7) | 4 (30.8) |
| ≥5 | 41 (45.5) | 9 (69.2) |
| Tumor number† | ||
| 1 | 46 (51.1) | 5 (38.5) |
| 2 | 11 (12.2) | 0 (0) |
| 3 | 3 (3.3) | 0 (0) |
| ≥4 | 30 (33.4) | 8 (61.5) |
| Tumor type† | ||
| Well defined | 78 (86.7) | 6 (46.2) |
| Ill defined | 12 (13.3) | 7 (53.8) |
| Portal/hepatic vein invasion† | ||
| No | 63 (70.0) | 7 (53.8) |
| Yes | 27 (30.0) | 6 (46.2) |
| Tumor differentiation‡ | ||
| I | 9 (9.8) | — |
| II | 51 (55.4) | — |
| III | 29 (31.6) | — |
| IV | 3 (3.3) | — |
| α-fetoprotein (ng/mL) | ||
| <20 | 43 (43.4) | — |
| 20–400 | 28 (28.3) | — |
| >400 | 28 (28.3) | — |
| Modified UICC stage | ||
| I | 5 (5.1) | 0 (0) |
| II | 37 (37.3) | 3 (23.1) |
| III | 16 (16.2) | 3 (23.1) |
| IVa | 13 (13.1) | 3 (23.1) |
| IVb | 28 (28.3) | 4 (30.7) |
| BCLC stage | ||
| Very early | 5 (5.1) | — |
| Early | 16 (16.3) | — |
| Intermediate | 35 (35.7) | — |
| Advanced | 42 (42.9) | — |
| Terminal | 1 (1.0) | — |
↵* One patient had both hepatitis B virus and hepatitis C virus.
↵† Among 99 HCC patients, 9 patients had only distant metastases without primary liver lesion after previous resection and 90 patients had primary HCC.
↵‡ Edmonson–Steiner grade: 7 of 90 patients with primary HCC had inappropriate biopsy specimen for evaluation of pathologic grade, and 92 patients (83 primary HCC and 9 metastatic HCC) were finally evaluated.
ECOG = Eastern Cooperative Oncology Group.
Data in parentheses are percentages.