TABLE 1

Body Weight and Serum Lipid Levels

		Mean ± SD in mice that were:
Parameter	Mouse group	10 wk old	18 wk old	25 wk old
Body weight (g)	Normal diet–wild-type	21.34 ± 0.67	26.19 ± 1.77^*	28.58 ± 1.58^*^†
	ChD–wild-type	26.92 ± 1.23^‡	36.48 ± 3.13^*^‡	40.39 ± 3.28^*^†^‡
	ChD–apoE^−/−	28.76 ± 2.02^‡^§	41.02 ± 6.57^*^‡	46.04 ± 5.35^*^‡^§
Total cholesterol level (mg/dL)	Normal diet–wild-type	73.42 ± 5.58	68.50 ± 6.36	78.42 ± 11.84
	ChD–wild-type	143.00 ± 17.77^‡	157.77 ± 18.51^‡	179.38 ± 27.10^*^†^‡
	ChD–apoE^−/−	1,386.17 ± 330.98^‡^§	2,097.00 ± 539.89^*^‡^§	1,716.00 ± 383.81^*^†^‡^§
LDL cholesterol level (mg/dL)	Normal diet–wild-type	15.10 ± 5.53	12.52 ± 5.20	19.32 ± 4.31^†
	ChD–wild-type	44.32 ± 12.33^‡	59.34 ± 12.26^*^‡	73.65 ± 18.93^*^†^‡
	ChD–apoE^−/−	1,358.22 ± 337.42^‡^§	2,056.33 ± 535.88^*^‡^§	1,677.95 ± 375.12^*^†^‡^§
HDL cholesterol level (mg/dL)	Normal diet–wild-type	40.67 ± 2.15	42.10 ± 3.54	47.42 ± 7.20^*
	ChD–wild-type	82.78 ± 11.67^‡	88.54 ± 7.70^‡	98.92 ± 11.41^*^†^‡
	ChD–apoE^−/−	9.44 ± 4.25^‡^§	9.67 ± 2.15^‡^§	11.77 ± 3.27^‡^§