Effect of Gefitinib on Binding, Internalization, and Nuclear Localization of 111In-DTPA-hEGF in MDA-MB-468 Human Breast Cancer Cells
| Proportion (%) | Proportion of cell-bound 111In-DTPA-hEGF (%) | |||
|---|---|---|---|---|
| Treatment | Radioactivity bound to cells | Cell-bound radioactivity internalized by cells | Radioactivity within cytoplasm | Radioactivity within nucleus |
| 111In-DTPA-hEGF | 54.7 ± 8.6 | 76.9 ± 5.9 | 62.3 ± 9.5 | 14.6 ± 4.0 |
| 111In-DTPA-hEGF + gefitinib | 58.1 ± 2.8 | 81.1 ± 1.0 | 55.0 ± 6.2 | 26.0 ± 5.5* |
↵* P < 0.05.
Data are expressed as mean ± SD of 3 experiments.