TABLE 2

In Vivo Nuclear Uptake in MDA-MB-361 Tumor-Bearing Mice 72 Hours After Intravenous Injection

Tissue	¹¹¹In-Trastuzumab	¹¹¹In-NLS₃-Trastuzumab	¹¹¹In-NLS₆-Trastuzumab	¹¹¹In-NLS₃-hIgG
Liver	0.78 ± 0.17	1.11 ± 0.30	1.14 ± 0.35	1.21 ± 0.30
Kidney	0.80 ± 0.28	1.16 ± 0.13	1.00 ± 0.35	1.14 ± 0.24
Spleen	0.51 ± 0.22	0.85 ± 0.13	1.08 ± 0.05	0.87 ± 0.22
Heart	0.15 ± 0.02	0.12 ± 0.04	0.15 ± 0.07	0.11 ± 0.02
Tumor	1.13 ± 0.32^a	2.42 ± 0.24^b	2.89 ± 0.35^c	0.48 ± 0.08^d

^{a-b, a-c, b-d, c-d}Significantly different.
^{a-d, b-c}Not significantly different.
Statistical comparisons between groups were made by Student t test (P < 0.05). Results are expressed as mean %ID/g ± SEM (n = 3).