TABLE 1

Tumor and Normal Tissue Uptake in MDA-MB-361 Tumor-Bearing Mice 72 Hours After Intravenous Injection

Tissue	¹¹¹In-Trastuzumab	¹¹¹In-NLS₃-Trastuzumab	¹¹¹In-NLS₆-Trastuzumab	¹¹¹In-NLS₃-hIgG
Blood	2.30 ± 0.37	2.31 ± 0.48	2.20 ± 0.12	3.18 ± 0.51
Bladder	2.81 ± 0.53	2.26 ± 0.37	2.37 ± 0.22	3.83 ± 0.66
Large intestine	1.59 ± 0.13	1.20 ± 0.21	1.26 ± 0.07	1.36 ± 0.09
Small intestine	2.44 ± 0.21	1.87 ± 0.21	1.91 ± 0.16	2.05 ± 0.15
Stomach	1.06 ± 0.10	0.89 ± 0.16	0.84 ± 0.12	0.99 ± 0.10
Spleen	7.17 ± 0.47	6.68 ± 0.83	7.05 ± 1.08	7.13 ± 0.61
Liver	11.46 ± 0.51	11.02 ± 0.37	12.27 ± 0.41	12.60 ± 0.91
Kidney	7.95 ± 0.53	7.70 ± 0.80	8.01 ± 0.26	8.23 ± 0.84
Lung	3.20 ± 0.21	2.64 ± 0.33	2.81 ± 0.05	3.63 ± 0.33
Heart	2.35 ± 0.26	2.08 ± 0.37	2.27 ± 0.13	2.54 ± 0.33
Muscle	1.37 ± 0.18	1.03 ± 0.22	0.90 ± 0.07	1.33 ± 0.26
Skin	2.11 ± 0.21	2.10 ± 0.50	2.05 ± 0.20	2.90 ± 0.38
Bone marrow	2.73 ± 0.71	2.92 ± 0.12	2.68 ± 0.28	3.33 ± 0.54
Tumor	13.17 ± 2.22^a	12.14 ± 1.34^b	12.62 ± 0.44^c	4.78 ± 0.76^d

^{a-d, b-d, c-d}Significantly different.
^{a-b, a-c, b-c}Not significantly different.
Statistical comparisons between groups were made by Student t test (P < 0.05). Results are expressed as mean %ID/g ± SEM (n = 6, except bone marrow, where n = 3).