TABLE 4

Effect of Haloperidol on Organ Uptake of ¹²³I-MEL037 in Black Mice Bearing B16 Tumor (Decay-Corrected)

	Control		Haloperidol treated
Distribution	1 h	24 h	1 h	24 h
Tumor	14.7 ± 2.0	10.9 ± 2.4	11.3 ± 0.8^*	5.5 ± 1.7^†
Eyes	28.2 ± 3.9	32.8 ± 2.6	28.9 ± 2.6	27.3 ± 3.6^*
Liver	17.4 ± 1.7	0.67 ± 0.07	18.9 ± 1.2	0.56 ± 0.07^*
Kidney	8.3 ± 0.8	0.74 ± 0.05	8.8 ± 0.9	0.80 ± 0.08
Lungs	4.9 ± 0.2	0.24 ± 0.04	5.4 ± 0.4^*	0.26 ± 0.04
Heart	2.8 ± 0.2	0.13 ± 0.02	3.2 ± 0.2^*	0.13 ± 0.02
Blood	1.7 ± 0.1	0.11 ± 0.01	2.0 ± 0.1^†	0.11 ± 0.01
Brain	1.47 ± 0.07	0.06 ± 0.01	1.61 ± 0.09^*	0.06 ± 0.01

↵* P < 0.05.
↵† P < 0.01.
Data are mean %ID/g of tissue ± SD (n = 5).