TABLE 2

Biodistribution of ¹²³I-MEL037 in Mice: Uptake (%ID) in Organ (Decay-Corrected)

Tumor model	Time (h)	Tumor	Eyes	Thyroid	Spleen^*	Liver	Stomach	GIT
B16^†	1	2.7 ± 2.1	1.0 ± 0.1	0.06 ± 0.01	0.08–0.33	15 ± 2	5.2 ± 1.2	15 ± 3
	3	5.2 ± 2.4	1.8 ± 0.3	0.13 ± 0.07	0.05–0.34	13 ± 3	6.3 ± 1.9	19 ± 3
	6	5.5 ± 2.8	2.3 ± 0.3	0.18 ± 0.13	0.04–0.44	8.9 ± 1.8	2.7 ± 1.0	19 ± 3
	24	1.9 ± 1.1	1.4 ± 0.2	0.13 ± 0.04	0.005–0.07	0.73 ± 0.14	0.3 ± 0.1	1.9 ± 0.6
	48^‡	1.3 ± 0.5	1.2 ± 0.1	0.09 ± 0.03	0.005–0.03	0.24 ± 0.01	0.1 ± 0.1	0.3 ± 0.1
A375^§	1^‡	0.06 ± 0.04	0.03 ± 0.01	0.05 ± 0.01	0.08 ± 0.01	13.1 ± 2.0	3.9 ± 1.2	30 ± 5
	6^‡	0.14 ± 0.12	0.02 ± 0.00	0.08 ± 0.03	0.06 ± 0.00	9.8 ± 1.4	2.0 ± 0.5	24 ± 2
	24^‡	0.01 ± 0.00	0.01 ± 0.00	0.10 ± 0.03	0.01 ± 0.00	1.3 ± 0.3	0.23 ± 0.04	2.6 ± 0.7