MVE of RGD Multimers Based on Cell Adhesion and Cell-Binding Assays Using Human Glioblastoma U87MG Cells
| Parameter | RGD monomer | RGD dimer | RGD tetramer | RGD octamer |
|---|---|---|---|---|
| Antiadhesion IC50 (nmol/L) | 2,710 ± 720 | 695 ± 99 | 323 ± 85 | 106 ± 22 |
| Antiadhesion MVE | 1 | 3.9 | 8.4 | 25.6 |
| Cell binding IC50 (nmol/L) | 203 ± 32 | 103 ± 14 | 34.6 ± 2.6 | 10.0 ± 1.7 |
| Cell binding MVE | 1 | 1.97 | 5.87 | 20.3 |
Concentrations are expressed as mean ± SD (n = 3), and MVE is IC50 of RGD monomer divided by IC50 of RGD multimers.