Mean Distribution Volumes (mL · cm−3) at Baseline and After Disulfiram
| VT | VS | VS corrected for fP | ||||
|---|---|---|---|---|---|---|
| Site | Baseline | Disulfiram | Baseline | Disulfiram | Baseline | Disulfiram |
| Frontal cortex | ||||||
| Distribution volume | 7.5 ± 1.1 | 4.0 ± 15.1 | 6.9 ± 1.1 | 3.5 ± 13.4 | 56.7 ± 9.7 | 26.2 ± 7.6 |
| COV (%) | 3.5 ± 0.4 | 1.1 ± 0.4 | 3.7 ± 0.4 | 1.6 ± 0.6 | ||
| Parietal cortex | ||||||
| Distribution volume | 7.3 ± 1.2 | 4.0 ± 15.5 | 6.8 ± 1.3 | 3.5 ± 13.5 | 56.0 ± 12.7 | 26.1 ± 7.6 |
| COV (%) | 3.3 ± 0.2 | 1.2 ± 0.4 | 3.5 ± 0.2 | 1.6 ± 0.4 | ||
| Temporal cortex | ||||||
| Distribution volume | 8.3 ± 1.8 | 5.1 ± 18.8 | 7.7 ± 1.8 | 4.6 ± 16.9 | 62.9 ± 12.9 | 33.5 ± 8.6 |
| COV (%) | 3.4 ± 0.7 | 1.2 ± 0.4 | 3.6 ± 0.7 | 1.5 ± 0.4 | ||
| Cerebellum | ||||||
| Distribution volume | 2.4 ± 1.7 | 0.7 ± 2.7 | 1.9 ± 1.6 | 0.4 ± 1.7 | 14.6 ± 11.2 | 2.7 ± 1.6 |
| COV (%) | 9.9 ± 9.3 | 4.7 ± 2.9 | 14.7 ± 16.9 | 11.3 ± 7.2 | ||
| Putamen | ||||||
| Distribution volume | 2.2 ± 1.3 | 0.9 ± 3.5 | 1.8 ± 1.2 | 0.6 ± 2.4 | 13.0 ± 7.4 | 4.5 ± 1.5 |
| COV (%) | 10.7 ± 2.4 | 4.9 ± 1.4 | 13.3 ± 2.3 | 7.5 ± 1.3 | ||